Results 51 to 60 of about 323,203 (269)

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 2; peer review: 2 approved]

NIHR Open Research
Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and values ...
Terence W O'Neill, Robert Horne, Clare Jinks, Christian D Mallen, Zoe Paskins, Elaine Nicholls, Laurna Bullock, Stephanie Butler-Walley, Andrea Cherrington, Jane Fleming, Emma M Clark, Ida Bentley, Sarah Leyland, Cynthia P Iglesias-Urrutia, Simon Thomas, Jo Smith, David Webb, Sarah Lewis, Sarah Bathers, Michele Siciliano, Angela Clifford, Sarah Ryan, Joanne Protheroe, Nicky Dale, Janet Lefroy, Sarah Connacher, Ashley Hawarden   +26 more
doaj   +1 more source

The current use of feasibility studies in the assessment of feasibility for stepped-wedge cluster randomised trials: a systematic review

BMC Medical Research Methodology, 2019
Background Stepped-wedge cluster randomised trials (SW-CRTs) are a pragmatic trial design, providing an unprecedented opportunity to increase the robustness of evidence underpinning implementation and quality improvement interventions.
Caroline A. Kristunas, Karla Hemming, Helen Eborall, Sandra Eldridge, Laura J. Gray   +4 more
doaj   +1 more source

Re‐Irradiation in Pediatric Diffuse Midline Glioma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with recurrent diffuse midline gliomas (DMGs) have limited therapeutic options at recurrence. Re‐irradiation (RT2) may be used at progression, but with uncertainty about the benefit. Methods We conducted a multi‐institutional retrospective study of children aged < 18 with DMG treated at three centers (Toronto, Canada ...
Ajay Thomas Alex, Sean P. Hassan, Helen Benghiat, Liam Herbert, Jennifer Adamski, Shivani Bailey, Claire Esler, Louise Brookes, Molly Bamber, Grace Koudou, Karen Waite, Julie Bennett, Anirban Das, Derek S. Tsang   +13 more
wiley   +1 more source

Associate Principal Investigators and the HEAL-COVID trial: good for trainees, good for trials

Trials
Background The NIHR’s Associate Principal Investigator (API) Scheme in the United Kingdom was expanded nationally in 2020 with the aim of training clinicians to become Principal Investigators for clinical research in the future.
Joseph Newman, Philip Wild, HEAL-COVID Collaboration, Charlotte Summers, Mark Toshner   +4 more
doaj   +1 more source

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 1; peer review: 2 approved]

NIHR Open Research
Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and values ...
Terence W O'Neill, Robert Horne, Clare Jinks, Christian D Mallen, Zoe Paskins, Elaine Nicholls, Laurna Bullock, Stephanie Butler-Walley, Andrea Cherrington, Jane Fleming, Emma M Clark, Ida Bentley, Sarah Leyland, Cynthia P Iglesias-Urrutia, Simon Thomas, Jo Smith, David Webb, Sarah Lewis, Sarah Bathers, Michele Siciliano, Angela Clifford, Sarah Ryan, Joanne Protheroe, Nicky Dale, Janet Lefroy, Sarah Connacher, Ashley Hawarden   +26 more
doaj   +1 more source

Measuring skin necrosis in a randomised controlled feasibility trial of heat preconditioning on wound healing after reconstructive breast surgery: study protocol and statistical analysis plan for the PREHEAT trial

Pilot and Feasibility Studies, 2018
Background Essential strategies are needed to help reduce the number of post-operative complications and associated costs for breast cancer patients undergoing reconstructive breast surgery.
Suzie Cro, Saahil Mehta, Jian Farhadi, Billie Coomber, Victoria Cornelius   +4 more
doaj   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

A feasibility randomised controlled trial of Empowered Conversations: training family carers to enhance their relationships and communication with people living with dementia

Pilot and Feasibility Studies
Background The primary objective of this UK-based trial was to investigate the feasibility of conducting a multi-centre randomised controlled evaluation trial of Empowered Conversations (EC). EC is a 6-session group psychosocial intervention for informal
Lydia Morris, Cassie Eastham, Chris Sutton, Yeliz Prior, Yvonne Sylvestre, Gemma Shields, John Keady, Cathy Riley, Mal Walters, Warren Mansell   +9 more
doaj   +1 more source

Feasibility study of rehabilitation for cardiac patients aided by an artificial intelligence web-based programme: a randomised controlled trial (RECAP trial)—a study protocol

BMJ Open
Introduction Cardiac rehabilitation (CR) delivered by rehabilitation specialists in a healthcare setting is effective in improving functional capacity and reducing readmission rates after cardiac surgery. It is also associated with a reduction in cardiac
Enoch Akowuah, Thanos Athanasiou, Rebecca Maier, Christopher Wilkinson, Emmanuel Ogundimu, Lisa Chang, Pasan Witharana   +6 more
doaj   +1 more source

Exploring different objectives in non-inferiority trials

BMJ
Non-inferiority trials compare the efficacy of a new treatment with an existing one where the new treatment is expected to have broadly similar efficacy to the existing treatment, but where other benefits might make the new treatment desirable. These trials might aim to demonstrate that a new treatment is either an alternative to, or a replacement for,
Conor D Tweed, Matteo Quartagno, Michelle N Clements, Rebecca M Turner, Andrew J Nunn, David T Dunn, Ian R White, Andrew J Copas   +7 more
openaire   +3 more sources