Results 31 to 40 of about 371,247 (318)

Non-invasive cardiac assessment in high risk patients (The GROUND study): rationale, objectives and design of a multi-center randomized controlled clinical trial

Trials, 2008
Background Peripheral arterial disease (PAD) is a common disease associated with a considerably increased risk of future cardiovascular events and most of these patients will die from coronary artery disease (CAD).
Moll Frans L, van Es H Wouter, Cramer Maarten J, Rensing Benno J, Prokop Mathias, Mosterd Arend, Lubbers Daniel D, Mali Willem P, Buiskool Robert A, Dikkers Riksta, Bots Michiel L, van de Zaag-Loonen Hester J, Rutten Annemarieke, de Vos Alexander M, van de Pavoordt Eric D, Doevendans Pieter A, Velthuis Birgitta K, Mackaay Albert J, Zijlstra Felix, Oudkerk Matthijs   +19 more
doaj   +1 more source

UK back pain exercise and manipulation (UK BEAM) trial - national randomised trial of physical treatments for back pain in primary care: objectives, design and interventions

, 2003
Low back pain has major health and social implications. Although there have been many randomised controlled trials of manipulation and exercise for the management of low back pain, the role of these two treatments in its routine management remains ...
null null, UK Beam (Back pain Exercise and Manipulation) Trial Team, Burton, A. Kim   +2 more
core   +1 more source

Anxiety and depression in multiple sclerosis patients around diagnosis.

, 2011
OBJECTIVES: To prospectively identify anxiety and depressive symptoms, and their predictors, during the multiple sclerosis (MS) peridiagnostic period. METHODS: The Hospital Anxiety and Depression Scale (HADS) was administered during diagnostic workup (
on behalf of the SIMS Trial group, Martinelli V, Confalonieri P, Giordano A, Solari A, LUGARESI, Alessandra, Trojano M, Radice D, Granella F   +8 more
core   +1 more source

Prevalence of cognitive impairment: results from the MRC trial of assessment and management of older people in the community.

, 2005
BACKGROUND: cognitive impairment is an important part of the diagnostic criteria for dementia. The Mini-Mental State Examination (MMSE) is recommended to test for cognitive impairment and to monitor medication response.
Rait, Greta, Fletcher, Astrid, Smeeth, Liam, Brayne, Carol, Stirling, Susan, Breeze, Elizabeth, Ng, Edmond Siu-Woon, Tulloch, Alistair J, Nunes, Maria, Bulpitt, Chris J, Jones, Dee   +10 more
core   +1 more source

Objective and Subjective Comprehension of Jury Instructions in Criminal Trials [PDF]

New Criminal Law Review, 2014
It would seem important that jury instructions are clear and comprehensible to jurors if they are to effectively carry out their responsibility in criminal trials. Research suggests, however, that jurors may not fully understand instructions despite reporting high levels of comprehension.
McKimmie, Blake M., Antrobus, Emma, Baguley, Chantelle   +2 more
openaire   +4 more sources

Respiratory distress symptom intervention for non-pharmacological management of the lung cancer breathlessness-cough-fatigue symptom cluster: randomised controlled trial

, 2022
Objectives In lung cancer, three prominent symptoms, such as breathlessness, cough and fatigue, are closely related with each other forming a ‘respiratory distress symptom cluster’.
Yorke, J., Khan, A., Molasiotis, A., Smith, J., Haines, J., Punnett, G., MacKereth, P., Johnson, M. J., Lloyd Williams, M., Ryder, D., Krishan, A., Blackhall, F., Davies, L.   +12 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

A randomised controlled feasibility study of interpersonal art psychotherapy for the treatment of aggression in people with intellectual disabilities in secure care

Pilot and Feasibility Studies, 2020
Background Rates of aggression in inpatient secure care are higher than in other psychiatric inpatient settings. People with intellectual disabilities in secure care require adapted psychological treatments.
Simon S. Hackett, Ania Zubala, Katie Aafjes-van Doorm, Thomas Chadwick, Toni Leigh Harrison, Jane Bourne, Mark Freeston, Andrew Jahoda, John L. Taylor, Cono Ariti, Rachel McNamara, Lindsay Pennington, Elaine McColl, Eileen Kaner   +13 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Ethical considerations about the collection of biological samples for genetic analysis in clinical trials

Research Ethics Review, 2023
Progress in precision medicine is being achieved through the design of clinical trials that use genetic biomarkers to guide stratification of patients and assignation to treatment or control groups. Genetic analysis of biomarkers is, therefore, essential
Inés Galende-Domínguez, Octavio M Rivero-Lezcano   +1 more
doaj   +1 more source