Results 91 to 100 of about 371,247 (318)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The AI-Guided Clinical Trial Architect: A Genetic Algorithm and MCDM Platform for Adaptive, Multi-Objective Patient Cohort Selection and Trial Simulation

Journal of Pharmacy
Introduction: Clinical trial design faces a critical challenge in balancing multiple, often conflicting, objectives such as statistical power, patient safety, cohort diversity, recruitment speed, and cost. While Multi-Objective Genetic Algorithms (MOGA)
Mehdi Jalali-Varnamkhasti, Mohammad Jalai Varnamkhasti   +1 more
doaj   +1 more source

Lifestyle information and access to a commercial weight management group to promote maternal postnatal weight management and positive lifestyle behaviour: the SWAN feasibility RCT

Public Health Research, 2020
Background: Increasing numbers of UK women have overweight or obese body mass index scores when they become pregnant, or gain excessive weight in pregnancy, increasing their risk of adverse outcomes.
Debra Bick, Cath Taylor, Vanita Bhavnani, Andy Healey, Paul Seed, Sarah Roberts, Magdalena Zasada, Amanda Avery, Victoria Craig, Nina Khazaezadah, Sarah McMullen, Sheila O’Connor, Bimpe Oki, Eugene Oteng-Ntim, Lucilla Poston, Michael Ussher   +15 more
doaj   +1 more source

Analysing the rate of change in a longitudinal study with missing data, taking into account the number of contact attempts [PDF]

, 2009
In longitudinal and multivariate settings incomplete data, due to missed visits, dropouts or non-return of questionnaires are quite common. A longitudinal trial in which potentially informative missingness occurs is the Collaborative Ankle Support ...
Akacha, Mouna, Hutton, Jane
core  

Implementation of the 'Sapere Migliora' information aid for newly diagnosed people with multiple sclerosis in routine clinical practice: a late-phase controlled trial.

, 2014
BACKGROUND: The SIMS-Trial showed that the 'Sapere Migliora' information aid (IA) for newly diagnosed people with multiple sclerosis (PwMS) effectively improved patient knowledge and satisfaction with care.
Martinelli V, GRANELLA, Franco, Giordano A, TROIANO, Maria, Solari A, Trojano M, Radice D, Granella F, LUGARESI, ALESSANDRA, Confalonieri P, on behalf of the SIMS Practice group, on behalf of the SIMS Practice groupa, Lugaresi A   +12 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Reporting quality of stepped wedge design randomized trials: a systematic review protocol

Clinical Epidemiology, 2016
Alex Thabane,1,2 Brittany B Dennis,3,4 Olga Gajic-Veljanoski,3,9,10 James Paul,2,3 Lehana Thabane2,3,5-8 1Life Sciences Program, Queen’s University, Kingston, ON, Canada; 2Department of Anesthesia, McMaster University Hamilton ON, 3Department of ...
Thabane A, Dennis BB, Gajic-Veljanoski O, Paul J, Thabane L   +4 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Patient and healthcare professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: qualitative study of the CATHETER II trial

BMJ Open
Objectives To explore trial participants’ experience of long-term catheters (LTC), the acceptability of washout policies, their experience of the CATHETER II trial (a randomised controlled trial comparing the clinical effectiveness of various washout ...
John Norrie, Graeme Maclennan, David Cooper, Paul Little, Peter Murchie, Phyo Kyaw Myint, Mohamed Abdel-fattah, Mary Kilonzo, Muhammad Imran Omar, Diana Johnson, Sara J Maclennan, James Ndow, Graham Scotland, Amanda Young, Seonaidh Cotton, Nikesh Thiruchelvam, Catherine Paterson, Lynda Constable, Hashim Hashim, Sheela Tripathee, Konstantinos Dimitropoulos, Suzanne Evans, Karen Powell, James Hugh Larcombe   +23 more
doaj   +1 more source

Regional lymphadenectomy vs. extended lymphadenectomy for hilar cholangiocarcinoma (Relay-HC trial): study protocol for a prospective, multicenter, randomized controlled trial

Trials, 2019
Background The prognostic benefits and safety of extended lymphadenectomy for hilar cholangiocarcinoma remain uncertain. The available evidence is still insufficient concerning its retrospective aspect.
Min He, Xinsen Xu, Hao Feng, Wei Chen, Houbao Liu, Yongjie Zhang, Jianming Wang, Zhimin Geng, Yudong Qiu, Weidong Duan, Xiangcheng Li, Xuting Zhi, Weihua Zhu, Fuyu Li, Jiangtao Li, Shengping Li, Yu He, Zhiwei Quan, Jian Wang   +18 more
doaj   +1 more source