Results 141 to 150 of about 188,471 (314)
What is the content of the common law obligation of good faith in commercial franchises?
, 2005 This article examines how lower courts in Australia have given content to the implied common law obligation of good faith in contractual performance and enforcement in the context of franchise relationships.
Dixon, William M.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Can the common law obligation of good faith be contractually excluded?
, 2007 Academic discussion about the meaning and content of the implied common law obligation of good faith continues to flourish. However, relatively little attention has been paid to the drafting implications of the implied obligation, and, in particular ...
Dixon, William M.
core
, 2023 Le Code civil prévoit deux modèles d'obligations au tout : il s'agit de l'obligation solidaire et de l'obligation indivisible. Ces dernières sont toujours conjointes, en ce sens qu'elles lient conjointement plusieurs sujets, ce qui implique qu'elles sont
Visciano, Théo
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Academic freedom academic obligation
, 2018 My first dilemma when it came to writing up this chapter for publication was how to punctuate the title. I first settled on ‘Academic freedom: academic obligation’, with the colon doing the work of an explanation, making the point that it is an academic ...
Carrol Clarkson, Clarkson, C.
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source