Results 121 to 130 of about 188,471 (314)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Perspectives in Clinical ResearchRandomized controlled trials (RCTs) are considered gold standard study designs. With increasing knowledge and experience, the requirements for designing, conduct and reporting of RCTs is becoming more demanding.
Jennee Moirangthem +2 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Cognitive Biases and Political Obligation
This chapter looks at the question of political obligations through a functional lens, focusing particularly on law’s function as a bias-countering device.
Gur, N
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Mutual obligation: why reciprocity is an inadequate principle for unemployment programmes
, 2003 Individualised reciprocity is the moral bedrock of recent Australian unemployment policies including the Howard Government’s principle of Mutual Obligation.
Hammer, Sara
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Queensland teachers' new legal obligation to report child sexual abuse
, 2004 Legislative amendments commencing in 2004 impose a new obligation on teachers and staff in Queensland schools to report known or suspected sexual abuse of a student by a school employee.
Walsh, Kerryann M., Mathews, Benjamin P.
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Raz on political obligation [PDF]
, 2002 The thesis discusses Raz's accounts of practical reason, obligation in general and political obligation (within political obligation, treating only the obligation to obey the law, the area of the subject on which Raz concentrates).
Parkhill, Richard James
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