Results 101 to 110 of about 188,471 (314)
, 2012 After the demise of the social contract theory, the argument from fair play, which employs the principle of fair play, has been widely acknowledged as one of the most promising ways of justifying political obligation.
Takikawa, Hirohide
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Homeschooling: entre dois jusnaturalismos?
Pro-PosiçõesResumo Este artigo pretende tomar como alvo a tensão existente entre o direito à educação e o dever da família de colocar as crianças na escola. Essa tensão, no caso do movimento intitulado homeschooling, toma partido do direito e, neste sentido ...
Carlos Roberto Jamil Cury
doaj +1 more source
Obligations and Conditionals [PDF]
Vivarium, 2015 The paper considers two kinds of medieval obligational disputations (positio, rei veritas) and the medieval genre of sophismata in relation to the kinds of inferences accepted in them. The main texts discussed are the anonymous Obligationes parisienses from the early 13th century and Richard Kilvington’s Sophismata from the early 14th century.
openaire +2 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Injustice and the Moral Obligation to Obey the Law
It is commonly thought that injustice undermines the moral obligation to obey the law. However, injustice is ubiquitous in legal and social institutions. Does the ubiquity of injustice therefore entail philosophical anarchism?
Crowe, Jonathan
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
مجلة كلية الفقه, 2007 this study deals with tenor connection between the hajj concept in its linguistical significance and its concept in the terms of the traditional or classical perspective for those who are interested in sharia (Islamic laws) according to its significance
Dr. Sirwan Abdulzahra Aljanabi
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Calculating the Cost of the Universal Service Obligation: The Need for a Global Approach [PDF]
The paper presents the basic approaches to calculate the cost of the USO and compares them with the requirements of the 3rd postal directive. We conclude that the profitability cost approach will lead to consistent estimations if it is applied in a ...
Christian Jaag +2 more
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