Results 111 to 120 of about 1,662,166 (403)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
In Defense of the Epistemic Imperative [PDF]
, 2018 Sample (2015) argues that scientists ought not to believe that their theories are true because they cannot fulfill the epistemic obligation to take the diachronic perspective on their theories. I reply that Sample’s argument imposes an inordinately heavy
A Chakravartty +26 more
core +2 more sources
Distributing Collective Obligation
, 2017 IN 1939, GERMANY INVADED CZECHOSLOVAKIA. Several major powers denounced the invasion. But the (mostly moribund) League of Nations proved ineffectual at coordinating intervention, and the (severely weakened) Czechoslovakian state was unable to mount real ...
Sean Aas
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Refusal of orders: The case of William Douglas Home [PDF]
, 1998 Based largely on the William Douglas Home court martial documents of 1944 and the three autobiographies that Douglas Home wrote, this article is an examination of the widely accepted principle that soldiers who are given orders that are ‘manifestly ...
Smith, Ron C.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Homeschooling: entre dois jusnaturalismos?
Pro-PosiçõesResumo Este artigo pretende tomar como alvo a tensão existente entre o direito à educação e o dever da família de colocar as crianças na escola. Essa tensão, no caso do movimento intitulado homeschooling, toma partido do direito e, neste sentido ...
Carlos Roberto Jamil Cury
doaj +1 more source
مجلة كلية الفقه, 2007 this study deals with tenor connection between the hajj concept in its linguistical significance and its concept in the terms of the traditional or classical perspective for those who are interested in sharia (Islamic laws) according to its significance
Dr. Sirwan Abdulzahra Aljanabi
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source