Results 161 to 170 of about 1,519,165 (389)

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

open access: yesMolecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul   +11 more
wiley   +1 more source

Variant Choices of Future Time Reference in Galician: The Grammaticalization of [haber (de) + infinitive] as a Window to Diachronic Change

open access: yesLanguages
Compared to neighboring Romance languages, Galician currently maintains a more ubiquitous usage of the construction [haber (present) + (de) + infinitive] as a future marker in variation with the periphrastic construction with ir ‘go’ and the ...
Esther L. Brown, Javier Rivas
doaj   +1 more source

Not a choice, an obligation

open access: yesAcademic Medicine, 1992
The author traces the gradual increase of educational opportunities for underrepresented minorities that began in the mid-1950s and indicates the role played by the Association of American Medical Colleges (AAMC) and individual medical schools in the 1960s and 1970s to increase minority enrollment in medical schools.
openaire   +4 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

open access: yesMolecular Oncology, EarlyView.
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley   +1 more source

Working parenthood and parental obligation. [PDF]

open access: yes
This article reports upon aspects of a small-scale qualitative study of low-income working families. The study was conducted in the context of recent policy changes in Britain that are intended to promote labour force participation by low-income parents,
Dean, Hartley
core   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

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