Results 51 to 60 of about 188,471 (314)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Mindset of Obligation: Conceptualization and Empirical Validation of a New Measure of Initiation and Perseverance.

open access: yes, 2022
We theoretically develop and empirically validate a measure of mindset of obligation, building on the concept of the form of commitment that receives the least attention from scholars – normative commitment.
Rubino, C   +7 more
core   +1 more source

Formation of lease agreement in pre-classical Roman law

open access: yesRUDN Journal of Law
Modern civil law is characterized by the emergence of undefined and mixed types of contracts. This development necessitates the identification of specific features that can help to classify contracts for legal certainty.
Mikhail M. Pestov
doaj   +1 more source

The Responsibility of a Service Provider in Classical Roman Law

open access: yesТеоретическая и прикладная юриспруденция, 2023
The article is devoted to the responsibility of a service provider in Classical roman law. The author describes the main social and legal factores led to the changes in a service agreement in comparing with its structure in Preclassical period of roman ...

doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Is the Duty to Prevent Genocide an Obligation of Result or an Obligation of Conduct according to the ICJ? (blogpost) [PDF]

open access: yes, 2019
This post analyses the duty to prevent genocide embodied in the 1948 UN Genocide Convention as described by the International Court of Justice in the Bosnia v. Serbia case.
Longobardo, M.
core  

Dogma, or the deep rootedness of obligation

open access: yes, 2018
This chapter seeks to make sense of the 'break' in terms of the primacy of obligation as rooted in the 'dogmatic', in the way that Alain Supiot has developed it; and shows that argument alongside the ideal of rootedness, more accurately that of 'taking ...
Christodoulidis, Emilios
core   +1 more source

Hanefî-Mâtürîdî Kelâm Okulunda Aklî Teklif

open access: yesYakın Doğu Üniversitesi İlahiyat Fakültesi Dergisi
İslam düşüncesinde teklif konusunun farklı mezhepler tarafından vahiy ve akıl ekseninde değerlendirilmesi, bağımsız insan varlığının ilahi sorumluluğunun kaynağıyla ilgili problemlere çözüm bulmaya yönelik bir faaliyettir.
Yunus Eraslan
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

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