Results 71 to 80 of about 250,819 (249)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Cutting the head as cure for headache
Ianna Journal of Interdisciplinary Studies, 2019 Background: Militancy has continued to define discourse about Niger Delta region. Government efforts aimed at combating the problem has so far been unable to address the issue. Despite this, empirical evidence on the impact of militant activities on the
Ijeoma Pauline Ogbonne
doaj +2 more sources
Just Say No (For Now): The Ethics of Illegal Drug Use
Law, Ethics and Philosophy, 2018 The war on drugs is widely criticized as unjust. The idea that the laws prohibiting drugs are unjust can easily lead to the conclusion that those laws do not deserve our respect, so that our only moral reason to obey them flows from a general moral ...
Mathieu Doucet
doaj +1 more source
A sociolinguistic perspective on the (quasi-)modals of obligation and necessity in Australian English [PDF]
, 2020 This article examines the distribution and sociolinguistic patterning of (quasi-)modals which express strong obligation/necessity, namely must, have to, have got to, got to and need to, in Australian English.
Korhonen, Minna, Penry Williams, Cara
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Saying sorry: Shifting obligation after conciliatory acts satisfies perpetrator group members. [PDF]
, 2013 How are intergroup conciliatory acts (apologies and reparations) evaluated by members of the perpetrator group offering them? This research tests whether these outcomes can be predicted by obligation shifting: the perception that a conciliatory act has ...
Giner-Sorolla, Roger, Zaiser, Erica
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Dogma, or the deep rootedness of obligation
, 2018 This chapter seeks to make sense of the 'break' in terms of the primacy of obligation as rooted in the 'dogmatic', in the way that Alain Supiot has developed it; and shows that argument alongside the ideal of rootedness, more accurately that of 'taking ...
Christodoulidis, Emilios
core +1 more source