Results 61 to 70 of about 1,519,165 (389)

Kants Begriff der Verbindlichkeit und die neuzeitliche Naturrechtslehre [PDF]

open access: yesКантовский сборник, 2015
My article is devoted to one of the main concepts of early modern natural law, i. e. the concept of obligation. Starting with Pufendorf's concept of obligation, it will be demonstrated that the natural law is grounded on the will of God. In contrast, the
Hüning D.
doaj   +1 more source

A review of the European Union landing obligation focusing on its implications for fisheries and the environment

open access: yes, 2018
Discarding is a common practice in fisheries. Total discards are estimated to be about 30 million tons, representing around 23% of worldwide catches. Discarding is an undesirable practice, not only because of the waste of resources, but also because of ...
J. Guillen   +8 more
semanticscholar   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

Homeschooling: entre dois jusnaturalismos?

open access: yesPro-Posições
Resumo Este artigo pretende tomar como alvo a tensão existente entre o direito à educação e o dever da família de colocar as crianças na escola. Essa tensão, no caso do movimento intitulado homeschooling, toma partido do direito e, neste sentido ...
Carlos Roberto Jamil Cury
doaj   +1 more source

Prescriptive Signs of an 18th Century English-Language Scientific Medical Text

open access: yesНаучный диалог, 2020
The article is devoted to the problem of studying a written scientific English text in medicine. Attention is paid to the features of its formation as a result of long historical development.
L. V. Yagenich
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

LEGAL FEATURES OF COMPETITIVE OBLIGATIONS UNDER THE CIVIL LAW OF THE REPUBLIC OF KAZAKHSTAN

open access: yesХабаршы. Заң сериясы, 2021
The article analyzes specific aspects of civil regulation of the competitive obligation. The high importance and lack of practical development of the above problem determine scientific work’s undoubted novelty. Further attention to the civil principle of
G.B. Mukaldyeva   +2 more
doaj   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

open access: yesFEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

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