FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Novation According to the Law of Ancient Rome
Проблеми Законності, 2016 Many of modern legal concepts have their roots in the jurisprudence of Ancient Rome. The concept of novation is one of them. That is why it is vitally important to analyze the main provisions concerning novation that were stated in ancient first-hand ...
Сабріна Еглерівна Сибіга
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Understanding the wounded soul of an invisible workforce: Needs and issues of family carers
Archives of Mental Health, 2019 Family caregivers have been an integral part of healthcare in India for several decades. They have been complementing the state resources, and thus, estimating the real healthcare cost becomes difficult.
N Janardhana
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The Domain of Obligations and Civil Liability of Client and Lawyer arising from Personal and Other’s Act against Each Other and Third Parties in Islamic Jurisprudence and French Law [PDF]
پژوهش تطبیقی حقوق اسلام و غرب, 2018 Trust possession (Yade Amani) and the liability arising from encroachment and wastage and the lawyers obligation in observing the trust and expedience of the client and the status of the contracts that the lawyer has signed outside of the scope of his ...
alireza yazdanian
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Conditions and Causes for Obligation to Mitigate Damages and the Effect of Negligence in It under Iranian and German Law [PDF]
پژوهش های حقوق تطبیقیIn case of breaching the contract, the injured party is entitled to receiving the compensation that places him in a status similar to full performance situation. However, if the injured party has a role to increasing the damage, either by failing to take
Mozhdeh Jamsahar +2 more
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The obligation of the entrepreneur to protect the environment [PDF]
Revista Institutului Naţional de JustiţieProtecting the environment is one of the most current topics of debate around the world. From the impact people have through all their actions, to how the planet can be protected, discussions about the environment are of great interest to everyone.
Grâu-Panțureac Maria
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Evaluating the Legitimacy of a Husband’s Opposition to His Wife’s Employment Despite the Stipulation of Her Right to Work in the Marriage Contract [PDF]
فقه و حقوق خانوادهOne of the issues that has received only superficial attention in family law is the stipulation of the wife’s right to work within the marriage contract.
Javad Sarkhosh +2 more
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