Results 71 to 80 of about 347,947 (294)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

A comparable-corpus based approach to the expression of obligation across English and French

open access: yesNJES: Nordic Journal of English studies, 2015
A French-English comparable corpus of political discourse is used to investigate the expression of obligation across the two languages. The aims of the study are to look at the expression of obligation in the comparable genres in the two languages and ...
Diana M. Lewis
doaj   +1 more source

The challenges of the landing obligation in EU fisheries

open access: yes, 2017
A feasibility study was conducted on the impacts of the new Common Fisheries Policy (CFP) rules requiring catches in regulated fisheries to be landed and counted against quotas of each Member State - the landing obligation (LO), and that catch of species
T. Catchpole   +4 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The Obligation of Adopted Children to Fulfill Parents' Alimentary Rights

open access: yesBatulis Civil Law Review
Introduction: Child adoptions have been carried out in different ways and motivations, in accordance with the current legal system and regulations in society.
Merry Tjoanda   +2 more
doaj   +1 more source

Rehabilitation as a positive obligation

open access: yes, 2017
Although the emphasis in European penal policy now lies on the rehabilitative aim of imprisonment, the concept of rehabilitation remains vague and is being interpreted differently in different European countries. This paper looks at rehabilitation from a
S. Meijer
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cutting the head as cure for headache

open access: yesIanna Journal of Interdisciplinary Studies, 2019
Background: Militancy has continued to define discourse about Niger Delta region. Government efforts aimed at combating the problem has so far been unable to address the issue. Despite this, empirical evidence on the impact of militant activities on the
Ijeoma Pauline Ogbonne
doaj   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Political obligation

open access: yes, 2014
The moral obligation to obey the law, or as it is generally called, political obligation, is a moral requirement to obey the laws of one’s country. Traditionally, this has been viewed as a requirement of a certain kind, to obey the law because it is the law, as opposed to the content of particular laws.
openaire   +1 more source

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