This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Conditions and Causes for Obligation to Mitigate Damages and the Effect of Negligence in It under Iranian and German Law [PDF]
In case of breaching the contract, the injured party is entitled to receiving the compensation that places him in a status similar to full performance situation. However, if the injured party has a role to increasing the damage, either by failing to take
Mozhdeh Jamsahar +2 more
doaj
The obligation of the entrepreneur to protect the environment [PDF]
Protecting the environment is one of the most current topics of debate around the world. From the impact people have through all their actions, to how the planet can be protected, discussions about the environment are of great interest to everyone.
Grâu-Panțureac Maria
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Evaluating the Legitimacy of a Husband’s Opposition to His Wife’s Employment Despite the Stipulation of Her Right to Work in the Marriage Contract [PDF]
One of the issues that has received only superficial attention in family law is the stipulation of the wife’s right to work within the marriage contract.
Javad Sarkhosh +2 more
doaj +1 more source
Rehabilitation as a positive obligation
Although the emphasis in European penal policy now lies on the rehabilitative aim of imprisonment, the concept of rehabilitation remains vague and is being interpreted differently in different European countries. This paper looks at rehabilitation from a
Sonja Meijer
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A comparable-corpus based approach to the expression of obligation across English and French
A French-English comparable corpus of political discourse is used to investigate the expression of obligation across the two languages. The aims of the study are to look at the expression of obligation in the comparable genres in the two languages and ...
Diana M. Lewis
doaj +1 more source
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The Obligation of Adopted Children to Fulfill Parents' Alimentary Rights
Introduction: Child adoptions have been carried out in different ways and motivations, in accordance with the current legal system and regulations in society.
Merry Tjoanda +2 more
doaj +1 more source

