Results 101 to 110 of about 554,914 (313)
Is the Duty to Prevent Genocide an Obligation of Result or an Obligation of Conduct according to the ICJ? (blogpost) [PDF]
, 2019 This post analyses the duty to prevent genocide embodied in the 1948 UN Genocide Convention as described by the International Court of Justice in the Bosnia v. Serbia case.
Longobardo, M., Longobardo, M.
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
ECTHR’S PERSPECTIVE ON THE REFUSAL OF A DOMESTIC COURT TO MAKE A PRELIMINARY REFERENCE TO THE CJEU [PDF]
Challenges of the Knowledge SocietyNowadays, even if the EU is not yet a party to the ECHR and its acts cannot be subject of applications to the Strasbourg Court, issues relating to EU law have been raised regularly with the Strasbourg Court. Art. 6 para.
Laura-Cristiana SPĂTARU-NEGURĂ
doaj
Studia Prawa Publicznego, 2019 The article focuses on the analysis of the parent situation (or statutory representatives) who are under legal requirement to subject their children to preventive vaccination.
Joanna Haberko
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Persistent inflammatory pap smears: there will be obligation to refer?
, 2018 Overview: Although low sensitivity of cervical cytology, this screening test was responsible by 70 to 80% reduction of incidence and mortality of cervical cancer worldwide. Inflammation is a common finding, that could be meaningless, could occlude premalignant lesions or could represent an oncological risk.
Santos, Fernanda, Pacheco, Amália
openaire +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The boundaries of Most Favored Nation treatment in international investment law [PDF]
, 2012 Copyright © 2012 MJIL Online.No abstract ...
Cole, T
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Four Problems with the Draft Restatement’s Treatment of Treaty Self-Execution [PDF]
, 2015 The American Law Institute has embarked on the challenging task of restating the confounding distinction between self-executing and non-self-executing treaties.
Vázquez, Carlos Manuel
core +2 more sources