Results 121 to 130 of about 20,287 (302)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
State Aid to enterprises in Croatia in 2001 [PDF]
State aid to enterprises is a form of government intervention. Under the Stabilization and Association Agreement with the EU Croatia has accepted certain obligations concerning the allocation and control of state aid.
Ivana Plese +2 more
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
The rights and obligations of the Constitutional Courts to Refer to the European Court of Justice for a preliminary ruling [PDF]
, 2018 Bakalaura darbā izvērtēts, kad Eiropas Savienības dalībvalsts konstitucionālajai tiesai ir tiesības un pienākums vērsties ES Tiesā ar lūgumu par prejudiciālā nolēmuma sniegšanu.
Arājs, Māris
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Having Gods, being greek and getting better : on equity and integrity concerning property and other posited laws in no foundations [PDF]
, 2012 This paper explores the classic dramatic tension that exists between, on the one side, a person’s prima facie obligation to obey posited law, and, on the other side, a person’s obligation to respect extra-legal norms, whether established by reference to ‘
Watt, Gary
core
Georgiou v. Greece:The ECtHR’s renewed interference with the obligation to refer preliminary questions [PDF]
, 2023 Claassen, J.T.; id_orcid
core +6 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source