Results 111 to 120 of about 20,287 (302)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
A critical study on the duty to refer in the light of traditional and Complementary Medicine Act 2013 / Afiifah Shariha Mohd Supi … [et al.] [PDF]
, 2014 This research has been conducted to analyse the existing legal framework in Malaysia governing the traditional and complementary medicine practice.
Mohd Supi, Afiifah Shariha +3 more
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COVID-19: Constructing a Specialised Sample Corpus to Test Trends in Deontic Obligation [PDF]
This paper reports on the construction and analysis of a specialised sample corpus made of corpuslinguistics, deontic modalitytranscripts from official UK Government statements from the COVID-19 daily briefings between March and April 2020.
Hammond, T.
core +2 more sources
LAW AND JUSTICE IN THE AGE OF POSTMODERNISM [PDF]
Challenges of the Knowledge SocietyThis study represents an attempt to highlight, from a legal and philosophical perspective, the most significant contradictions that can affect justice during a period of social crisis, namely the era of postmodernism.
Marius ANDREESCU, Andra PURAN
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The preliminary ruling procedure as part of a 'complete system of remedies': Does the obligation to seek a preliminary ruling ensure effective judicial protection of individuals? [PDF]
, 2005 Access to court is essential for the protection of all rights of individuals. The same holds true for the rights individuals derive from Community law.
Briem, Hildur
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Short Presentation of the World Trade Organization and of its Role in International Economical Relations [PDF]
World Trade Organization – one of the most important international economical organizations, based on the principles of the General Agreement for Tariffs and Trade (GATT) – represents the international institutional frame of the multilateral trade system
Trocan, Laura – Magdalena
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source