Results 91 to 100 of about 1,388,590 (311)
Ученые записки Российской академии предпринимательства, 2021 In the article problems of introduction and implementation of the international standards and procedures urged to increase transparency of financial operations for ensuring automatic exchange of information, increase of efficiency and decrease in zones ...
R. R. Arabov
doaj
Модернизация, инновация, развитие, 2018 Purpose: the main purpose of the article is to investigate modern problems of the institution of bankruptcy and the impact of its results on the system of economic security of the state, to develop recommendations for improving the institution of ...
V. N. Alferov, M. M. Korigova
doaj +1 more source
A structured argumentation framework for detaching conditional obligations
, 2016 We present a general formal argumentation system for dealing with the detachment of conditional obligations. Given a set of facts, constraints, and conditional obligations, we answer the question whether an unconditional obligation is detachable by ...
Beirlaen, Mathieu, Straßer, Christian
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Polylinguality and Transcultural Practices, 2014 The article is devoted to the research of problems connected with intercultural communication between foreign students learning at preparatory faculties of Russian higher educational establishments and teachers of Russian as a foreign language.
T G Kolosova
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Heroical Apatheism: Mala Fide Bootstrapping Obligations [PDF]
, 2018 Discussions on hypothetical gods virtually always focus on the latter’s existence or nonexistence. However, this is only the secondary question. Heroical apatheism distinguishes these questions from the primary question, which pertains to the importance ...
Von Hegner, Ian
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source