Results 121 to 130 of about 1,590,564 (275)

Observable scattered light features from inclined and non-inclined planets embedded in protoplanetary discs [PDF]

, 2019
Dylan Kloster, Mario Flock
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Decoding anxiety: A scoping review of observable cues

Digital Health
Background While anxiety disorders are one of the most prevalent mental diseases, they are often overlooked due to shortcomings of the existing diagnostic procedures, which predominantly rely on self-reporting.
Urška Smrke, Izidor Mlakar, Ana Rehberger, Leon Žužek, Nejc Plohl   +4 more
doaj   +1 more source

Bayesian method for quantifying the non-Gaussian fluctuations in low-intermediate energy heavy ion collisions

Physics Letters B
In this work, we present a model-independent method to quantify the non-Gaussian fluctuations in the observable distributions, which are assessed by the difference between the measured observable distributions and reconstructed observable distributions ...
Xinyu Wang, Xiang Chen, Junping Yang, Ying Cui, Zhuxia Li, Kai Zhao, Yingxun Zhang   +6 more
doaj   +1 more source

The observable structure of persistence modules

, 2014
In persistent topology, q-tame modules appear as a natural and large class of persistence modules indexed over the real line for which a persistence diagram is definable.
Chazal, Frederic, Crawley-Boevey, William, de Silva, Vin   +2 more
core   +1 more source

Dynamic Critical Behavior of Percolation Observables in the 2d Ising Model [PDF]

, 2004
W. G. Wanzeller
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Linking cumulative carbon emissions to observable climate impacts

Environmental Research: Climate
Anthropogenic CO _2 emissions are causing climate change, and impacts of climate change are already affecting every region on Earth. The purpose of this review is to investigate climate impacts that can be linked quantitatively to cumulative CO _2 ...
Claude-Michel Nzotungicimpaye, H Damon Matthews   +1 more
doaj   +1 more source

The lightest Higgs boson of mSUGRA, mGMSB and mAMSB at present and future colliders: observability and precision analyses [PDF]

, 2003
Athanasios Dedes, S. Heinemeyer, Shufang Su, G. Weiglein   +3 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source