Results 171 to 180 of about 740,500 (344)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Evaluation of contemporary treatment of high- and very high-risk patients for the prevention of cardiovascular events in Europe – Methodology and rationale for the multinational observational SANTORINI study

, 2021
Kausik K. Ray, Inaam Haq, Aikaterini Bilitou, Carlos Aguíar, Marcello Arca, Derek Connolly, Mats Eriksson, Jean Ferrières, Per Hildebrandt, Ulrich Laufs, José María Mostaza, David Nanchen, Ernst Rietzschel, Timo Strandberg, Hermann Toplak, Frank L.J. Visseren, Alberico L. Catapano   +16 more
openalex   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Methodological Challenges in Observational Studies: Measuring Socio-Economic Status and Alcohol Consumption

, 2017
Ulrike Grittner
openalex   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Effectiveness of a delegated primary care model in rural areas: design and methodology of a longitudinal observational study [PDF]

Julia Bräuer, Romina Lörzing, Eckhard Nagel, Martin Emmert, R. Hofmann   +4 more
openalex   +3 more sources

María Teresa Anguera Argilaga: pioneer of observational methodology and an example of wisdom and humanity. [PDF]

Front Psychol
Hernández-Mendo A, Losada JL.
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

DEVELOPMENT OF METHODOLOGY FOR PLANT PHENOLOGY MONITORING BY GROUND-BASED OBSERVATION USING DIGITAL CAMERA [PDF]

, 2019
M. Yamashita, Yasuo Shinomiya, Mitsunori Yoshimura   +2 more
openalex   +1 more source

An observational, non-interventional, multicenter, multinational registry of patients with atypical hemolytic uremic syndrome: methodology [PDF]

, 2013
Ardissino, Gianluigi, Ariceta, Gema, Beauchamp, Jon, Cohen, David, Fremeaux-Bacchi, Veronique, Greenbaum, Larry A, Johnson, Sally, Licht, Christoph, Ogawa, Massayo, Schaefer, Franz, Vande Walle, Johan   +10 more
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