Results 191 to 200 of about 4,109,796 (295)

The Role of the Antidepressants in Managing Chemotherapy-Induced Neuropathic Pain: A Systematic Review. [PDF]

Pharmacol Res Perspect
Caminiti R, Mazza V, Nucera S, Oppedisano F, Passacatini LC, Maiuolo J, Malafoglia V, Giorgio A, Soluri A, Pileggi C, Tomino C, Mollace V, Ilari S, Muscoli C.   +13 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Maternal and neonatal outcomes among women with suspected macrosomia undergoing induction of labor: a systematic review and meta-analysis. [PDF]

Front Glob Womens Health
Al Kadri HM, El-Metwally AA, Farook FF, Othman FM, AlSehli H, Al Sudairy AA, Aldubikhi AI.   +6 more
europepmc   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Comparative safety and effectiveness of midline catheters vs. peripherally inserted central catheters: a systematic review and meta-analysis. [PDF]

Front Cardiovasc Med
Aljameie M, Ahmed Shimal A, Mahmoud MH, Abbas OF, Oudah AM, Ahmed MJ, Hamzah KA, Mansour A, Abdullatif Abdulqader W, Aljubori E, Mohammed G, Alkhateeb FS, El-Ramly TA, Al-Sagban A, Graham H, Musri MC.   +15 more
europepmc   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Clinical evaluation of early implant stability using resonance frequency analysis: a multicenter observational study. [PDF]

Front Dent Med
Rodrigues SJ, Shenoy VK, Upadhya MK, Kulkarni MR, Kumar ABT, Ponnanna AA, Mamatha NS.   +6 more
europepmc   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Determinants of intensive care unit light exposure: an observational cohort study of patient, temporal, and structural factors. [PDF]

Front Neurol
Intihar TA, Rao OP, Gomez-Crase PA, Doyle MM, Wasden K, Wright KP, Redeker NS, Yaggi HK, Knauert MP.   +8 more
europepmc   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source