Results 91 to 100 of about 49,584,610 (301)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Current Status of the Treatment of COPD in China: A Multicenter Prospective Observational Study

International Journal of COPD, 2020
Yuqin Zeng,1– 3 Shan Cai,1– 3 Yan Chen,1– 3 Jiaxi Duan,1– 3 Yiyang Zhao,1– 3 Xin Li,4 Libing Ma,5 Qimi Liu,6 Yingqun Zhu,7 Ming Chen,8 Meiling Zhou,9 Ping Chen1– 3 1Department of Pulmonary and Critical Care Medicine ...
Zeng Y, Cai S, Chen Y, Duan J, Zhao Y, Li X, Ma L, Liu Q, Zhu Y, Chen M, Zhou M, Chen P   +11 more
doaj  

An Observational Study of Deep Learning and Automated Evaluation of Cervical Images for Cancer Screening.

Journal of the National Cancer Institute, 2019
Background Human papillomavirus vaccination and cervical screening are lacking in most lower resource settings, where approximately 80% of more than 500 000 cancer cases occur annually. Visual inspection of the cervix following acetic acid application is
Liming Hu, David Bell, Sameer Kiran Antani, Z. Xue, Kai Yu, M. Horning, Noni Gachuhi, Ben Wilson, Mayoore S. Jaiswal, B. Befano, L. Long, R. Herrero, M. Einstein, R. Burk, M. Demarco, J. Gage, A. Rodriguez, N. Wentzensen, M. Schiffman   +18 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Anthropometric indicators of obesity in policemen: A systematic review of observational studies

International Journal of Occupational Medicine and Environmental Health, 2014
The aim of this paper was to summarize scientific literature on obesity in policemen through a systematic review of observational studies. For this purpose the following electronic databases were selected: Medline by Pubmed, CINAHL, and Scopus; and a ...
Franciele Cascaes Da Silva, Salma Stéphany Soleman Hernandez, Elizandra Gonçalves, Beatriz Angélica Valdivia Arancibia, Thiago Luis Da Silva Castro, Rudney Da Silva   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Beverage purchases from stores in Mexico under the excise tax on sugar sweetened beverages: observational study

British medical journal, 2016
Study question What has been the effect on purchases of beverages from stores in Mexico one year after implementation of the excise tax on sugar sweetened beverages?
M. Colchero, Barry M. Popkin, Juan A. Rivera, S. Ng   +3 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Characteristics of Severe Non-Eosinophilic Asthma: Analysis of Data from 1075 Patients Included in the FASE-CPHG Study

Journal of Asthma and Allergy, 2023
Laurent Portel,1 Caroline Fabry-Vendrand,2 Nathalie Texier,3 Déborah Schwartz,3 Audrey Capdepon,2 Gabriel Thabut,2 Didier Debieuvre4 1Service de Pneumologie, Centre Hospitalier Robert Boulin, Libourne, France; 2Astra Zeneca, Courbevoie, France ...
Portel L, Fabry-Vendrand C, Texier N, Schwartz D, Capdepon A, Thabut G, Debieuvre D   +6 more
doaj  

Identifying prognostic factors for conservative treatment outcomes in servicemen with chronic exertional compartment syndrome treated at a rehabilitation center

Military Medical Research, 2017
Background Chronic exertional compartment syndrome (CECS) is a condition of pain induced by exercise, and it is characterized by muscle swelling and impaired muscle function in the lower leg. Given the diversity in the diagnosis and treatment of CECS, it
Mariëtte Z. Meulekamp, Peter van der Wurff, Alfred van der Meer, Cees Lucas   +3 more
doaj   +1 more source