Results 111 to 120 of about 1,473,678 (357)

Retrospective, multi-centre, open-label study on the use of alemtuzumab for relapsing–remitting multiple sclerosis in clinical practice: A 4-year follow-up

Neurology Perspectives
Introduction: The efficacy and safety of alemtuzumab for patients with relapsing–remitting multiple sclerosis (RRMS) have been demonstrated in clinical trials. However, due to the limitations of these studies, it is important to assess the effects of the
A. Pato-Pato, P. Gabeiras-Araujo, M. Lorenzo-García, C. Hernandez-Cerón, J.R. Lorenzo-González, D.A. García-Estévez   +5 more
doaj   +1 more source

Re: Limitations of current definitions of miscarriage using mean gestational sac diameter and crown–rump length measurements: a multicenter observational study [PDF]

, 2012
D. Jurkovic
openalex   +1 more source

Evaluation of Maxillary Bone in the Anterior Esthetic Zone for Immediate Implant Placement: An Observational CBCT Study

, 2021
Nupur Dabas, Monika Vigarniya, Shefali Phogat, Reshu Sanan, Maninder Singh Sidhu, Madhav Nagpal   +5 more
openalex   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A prospective, observational, multicentre study to evaluate the efficacy of brivaracetam as adjuvant therapy for epilepsy: The Bravo study

Background: Epilepsy is a persistent tendency to experience epileptic seizures and can lead to various neurobiological disorders, with an elevated risk of premature mortality. This study evaluates the efficacy of brivaracetam adjuvant therapy in patients
Abdul Latif Sunejo, Amjad Iqbal, Kaukab Fatima, Saira Abbass, Samar Altaf, Arjumand Ahmed, Jawwad Us Salam, Ahsan Numan, Bashir A Soomro, Faizan Hyder Memon, Muhammad Wahab Qureshi, Sidrah Nawaz, Neeta Maheshwary, Muhammad Iqbal Asif, Junaid Ahmed Sheikh, Safia Bano, Muhammad Athar Khan, Hazim Brohi, Fowzia Siddiqui, Saba Zaidi, Ehsan U Rehman, Muhammad Zaheer   +21 more
core   +1 more source

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial

, 2002
Background: Throughout the usual LDL cholesterol range in Western populations, lower blood concentrations are associated with lower cardiovascular disease risk.
Heart Protection Study Collaborative Group
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study

, 2013
Background: Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. Objective: To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany ...
Wissing, Heimo, Nocea, Gonzalo, Krobot, Karl J., Kaskel, Peter, Ballus, Jose, Bingold, Tobias Michael, Kumar, Ritesh N., Mavros, Panagiotis   +7 more
core   +1 more source

AN OBSERVATIONAL STUDY IN LIVERPOOL OF PREGNANT WOMEN WITH A BMI ≥ 35kg/m2 REGARDING DIETARY INTAKE, LIFESTYLE AND LIVED EXPERIENCE [PDF]

, 2016
Margaret Charnley
openalex   +1 more source