Results 151 to 160 of about 1,473,678 (357)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Effectiveness of rehabilitation dose heterogeneity for improving functional outcomes of patients with acute stroke: a nationwide observational study

Scientific Reports
To examine heterogeneity in the impact of increased early rehabilitation intensity and to identify which ischemic stroke patients benefit most. We analysed 39,140 propensity score-matched ischemic stroke patients using Diagnosis Procedure Combination ...
Takuaki Tani, Masashi Kanai, Masatoshi Kamada, Kazushige Ide, Kiyohide Fushimi   +4 more
doaj   +1 more source

Estimation of treatment effects in observational studies by recovering the assignment probabilities and the population model

, 2007
In observational studies the assignment of units to treatments is with unknown probabilities. Consequently, estimation and comparison of treatment effects based on the empirical distributions of the response under the various treatments can be biased ...
Landsman, Victoria, Pfeffermann, Danny
core  

A STUDY OF CONVECTIVE PRECIPITATION AS REVEALED BY RADAR OBSERVATION, TEXAS 1958–59 [PDF]

, 1960
Robert A. Clark
openalex   +1 more source

CORRELATION OF RELATIVE HEIGHT OF FOREHEAD AND AYURVEDIC PRAKRITI OF MALE INDIVIDUALS IN AYURVEDIC PRAMANA SHARIR- AN OBSERVATIONAL STUDY

, 2022
Anita
openalex   +2 more sources

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Severe Atopic Dermatitis In Spain: A Real-Life Observational Study

, 2019
Antoni Sicras-Mainar,1 Ruth Navarro-Artieda,2 José C Armario-Hita3 1Scientific Direction, Real Life Data, Madrid, Spain; 2Medical Documentation, Germans Trias i Pujol Hospital, Barcelona, Spain; 3Dermatology Service, Puerto Real University ...
Armario-Hita JC, Navarro-Artieda R, Sicras-Mainar A   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source