Results 111 to 120 of about 9,609,480 (297)
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Adaptive State Observer Design for Dynamic Links in Complex Dynamical Networks. [PDF]
Gao Z, Xiong J, Zhong J, Liu F, Liu Q.
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Observability Analysis and Observer Design for a Nonlinear Three-Tank System: Theory and Experiments. [PDF]
Rúa S +3 more
europepmc +1 more source
Design of a zero-sensitive observer
Abstract The Luenberger observer is frequently used for the state estimator of linear time-invariant control systems. However, it cannot be applied directly to the plant which has varying parameters. This paper provides an observer for this problem whose structure is not affected by the varying parameters of the plant.
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
A Sensor Fusion Approach to Observe Quadrotor Velocity
The growing use of Unmanned Aerial Vehicles (UAVs) raises the need to improve their autonomous navigation capabilities. Visual odometry allows for dispensing positioning systems, such as GPS, especially on indoor flights.
José Ramón Meza-Ibarra +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The Yeshiva University Observer ; March 2015
The official newspaper of Stern College for Women and the Sy Syms School of BusinessFounded by the women of Yeshiva University's Stern College In 1958, The Observer Is the official newspaper representing the student body of Stern College and ...
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