Results 121 to 130 of about 14,463,930 (343)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Interval observer design for discrete-time switched system

, 2017
In this paper, the problems of interval observer design for discrete-time switched system are investigated. In order to make the residual system stable and non-negative, a time-varying linear transformation and a standard switched system stability ...
S. Guo, Fanglai Zhu
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

RBCKF-Based Vehicle State Estimation by Adaptive Weighted Fusion Strategy Considering Composite-State Tire Model

World Electric Vehicle Journal
The acquisition of vehicle driving status information is a key function of vehicle dynamics systems, and research on high-precision and high-reliability estimation of key vehicle states has significant value.
Xi Chen, Xinlong Cheng
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Estimation of Sporulated Cell Concentration of Bacillus thuringiensis in a Batch Biochemical Reactor via Simple State Observers

Mathematics
This paper presents a contrast of two different observation strategies viz a nonlinear observer and a classical extended Luenberger observer applied to a bioreactor system for Bacillus thuringiensis production.
José Luis Zárate-Castrejón, Pablo A. López-Pérez, Milagros López-López, Carlos A. Núñez-Colín, Rafael A. Veloz-García, Hamid Mukhtar, Vicente Peña-Caballero   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Combining Model-Based and Data-Driven Observer Designs for Sideslip Angle Estimation

IEEE Access
The vehicle side slip angle represents a key indicator of dynamic stability. Elevated values of the side slip angle may indicate a loss of stability or undesired vehicle behaviors such as understeering or oversteering.
Martin Repka, Alexander L. Gratzer, Jan Fojtasek, Tomas Straka, Petr Portes, Alexander Schirrer   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Adaptive State Observer Design for Dynamic Links in Complex Dynamical Networks. [PDF]

Comput Intell Neurosci, 2020
Gao Z, Xiong J, Zhong J, Liu F, Liu Q.
europepmc   +1 more source