Results 161 to 170 of about 5,120,899 (402)

Intra-Tumour Heterogeneity Is One of the Main Sources of Inter-Observer Variation in Scoring Stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer. [PDF]

Cancers (Basel), 2021
Kilmartin D, O'Loughlin M, Andreu X, Bagó-Horváth Z, Bianchi S, Chmielik E, Cserni G, Figueiredo P, Floris G, Foschini MP, Kovács A, Heikkilä P, Kulka J, Laenkholm AV, Liepniece-Karele I, Marchiò C, Provenzano E, Regitnig P, Reiner A, Ryška A, Sapino A, Specht Stovgaard E, Quinn C, Zolota V, Webber M, Roshan D, Glynn SA, Callagy G.   +27 more
europepmc   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Reproducibility of rCBV in glioblastomas using T2*-weighted perfusion MRI: an evaluation of sampling, normalization, and experience

Diagnostic and Interventional Radiology
PURPOSEThe reproducibility of relative cerebral blood volume (rCBV) measurements among readers with different levels of experience is a concern. This study aimed to investigate the inter-reader reproducibility of rCBV measurement of glioblastomas using ...
Sabahattin Yüzkan, Samet Mutlu, Mehmet Karagülle, Merve Şam Özdemir, Hamit Özgül, Mehmet Ali Arıkan, Burak Koçak   +6 more
doaj   +1 more source

Time variation of the gravitational coupling constant in decrumpling cosmology [PDF]

arXiv, 2005
Within the framework of a model universe with time variable space dimension (TVSD) model, known as decrumpling or TVSD model, we study the time variation of the gravitational coupling constant. Using observational bounds on the present time variation of the gravitational Newton's constant in three-dimensional space we are able to obtain a constraint on
arxiv  

Robust Variational Inference [PDF]

arXiv, 2016
Variational inference is a powerful tool for approximate inference. However, it mainly focuses on the evidence lower bound as variational objective and the development of other measures for variational inference is a promising area of research. This paper proposes a robust modification of evidence and a lower bound for the evidence, which is applicable
arxiv  

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Artificial intelligence in foot and ankle pathology: Can large language models replace us?

Journal of the Foot & Ankle
Objective: Determine if large language models (LLMs) provide better or similar information compared to an expert trained in foot and ankle pathology in various aspects of daily practice (definition and treatment of pathology, general questions). Methods:
Florencio Pablo Segura, Facundo Manuel Segura, Julieta Porta, Natalia Heredia, Ignacio Masquijo, Federico Anain, Leandro Casola, Agustina Trevisson, Virginia Cafruni, Maria Paz Lucero Zudaire, Ignacio Toledo, Florencio Vicente Segura   +11 more
doaj   +1 more source

Variational inequalities for the commutators of rough operators with BMO functions [PDF]

arXiv, 2017
In this paper, starting with a relatively simple observation that the variational estimates of the commutators of the standard Calder\'on-Zygmund operators with the BMO functions can be deduced from the weighted variational estimates of the standard Calder\'on-Zygmund operators themselves, we establish similar variational estimates for the commutators ...
arxiv  

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source