Results 101 to 110 of about 317,686 (280)
Obstruction Theory for the $$\mathbb {Z}_2$$-Index of 4-Manifolds
Bulletin of the Iranian Mathematical SocietyWe develop a complete obstruction theory for the $\mathbb{Z}_2$-index of a compact connected 4-dimensional manifold with free involution. This $\mathbb{Z}_2$-index, equal to the minimum integer $n$ for which there exists an equivariant map with target the $n$-sphere with antipodal involution, is computed in two steps using cohomology with twisted ...
Chahrazade Matmat, Christian Blanchet
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Impact of airflow obstruction on long-term mortality in patients with asthma in Japan
Allergology International, 2019 Background: The long-term prognosis of asthma with airflow obstruction is poorly understood in Japan. The aim of this retrospective 26-year study was to investigate the long-term mortality risk of airflow obstruction in asthmatics.
Yusuke Okayama +7 more
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
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结直肠肛门外科[Objectives] To analyze the influencing factors for postoperative intestinal obstruction of colorectal cancer and construct a prediction model. [Methods] A retrospective analysis was conducted on 300 patients with colorectal cancer admitted to our ...
Wang Zhen +5 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Clinical Significance of the Obstructive Index in Obstructive Lung Diseases
Clinical Significance of the Obstructive Index in Obstructive Lung Diseases2023
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