Results 91 to 100 of about 655,218 (318)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Prevalence and characteristics of asthma–COPD overlap syndrome identified by a stepwise approach

International Journal of COPD, 2017
Hiromasa Inoue,1 Takahide Nagase,2 Satoshi Morita,3 Atsushi Yoshida,4 Tatsunori Jinnai,4 Masakazu Ichinose5 1Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, 2Department of Respiratory ...
Inoue H, Nagase T, Morita S, Yoshida A, Jinnai T, Ichinose M   +5 more
doaj  

Role of Nasal Surgery in Adult Obstructive Sleep Apnea: A Systematic Review

Sleep Science
Objective To perform a systematic review to determine if isolated nasal surgery has any impact on subjective or objective parameters in adult obstructive sleep apnea (OSA) patients.
Eduardo J. Correa, Diego M. Conti, Ramón Moreno-Luna, Serafín Sánchez-Gómez, Carlos O'Connor Reina   +4 more
doaj   +1 more source

Obstructive Nephropathy.

Internal Medicine, 2000
Obstructive nephropathy is a relatively common entity that is treatable and often reversible. It occurs at all ages from infancy to elderly subjects. Obstructive uropathy is classified according to the degree, duration and site of the obstruction. It is the result of functional or anatomic lesions located in the urinary tract. The causes of obstructive
openaire   +4 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Low lung function in Bipolar Disorder and Schizophrenia: a hidden risk

Frontiers in Physiology
Introduction: People with serious mental illness (SMI), such as schizophrenia and bipolar disorder, have a higher risk of premature morbidity and mortality.
Cristina Ruiz-Rull, Cristina Ruiz-Rull, María José Jaén-Moreno, María José Jaén-Moreno, Gloria Isabel del Pozo, Gloria Isabel del Pozo, Cristina Gómez, Cristina Gómez, Francisco Javier Montiel, Francisco Javier Montiel, Montserrat Alcántara, Montserrat Alcántara, Laura Carrión, Laura Carrión, Geli Marie Chauca, Geli Marie Chauca, Nuria Feu, Ipek Guler, Fernando Rico-Villademoros, Cristina Camacho-Rodríguez, Luis Gutierrez-Rojas, Luis Gutierrez-Rojas, David Mannino, Fernando Sarramea, Fernando Sarramea, Fernando Sarramea, Fernando Sarramea   +26 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Pathophysiology of obstructive sleep apnoea syndrome: a review

Sultan Qaboos University Medical Journal, 2000
Sleep apnoea syndrome is a common disorder and a major health hazard that affects many body systems. It is particularly associated with increased cardiovascular and cerebrovascular morbidity and mortality. Among its other manifestations include increased
Al Riyami B, Al Rawas O, Hassan MO
doaj  

Preoperative decompression for left-sided obstructive colorectal cancer: a comparative study between a stent and a decompression tube

Videosurgery and Other Miniinvasive Techniques
Introduction: Stents and decompression tubes (DTs) are both commonly utilized for preoperative decompression in patients with left-sided obstructive colorectal cancer (OCRC).
Xin-Chun Guo, Qiang Lu, Yu-Fei Fu, Xin Lu   +3 more
doaj   +1 more source