Results 81 to 90 of about 1,085,850 (360)

Obstructed labour [PDF]

British Medical Bulletin, 2003
Obstructed labour is an important cause of maternal deaths in communities in which undernutrition in childhood is common resulting in small pelves in women, and in which there is no easy access to functioning health facilities with the capability of carrying out operative deliveries.
Neilson, J. P., Lavender, T., Quenby, S., Wray, S.   +3 more
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Resveratrol Attenuates Both Small Bowel and Liver Changes in Obstructive Jaundice

Balkan Medical Journal, 2014
Background: It is well known that mucosal changes and alterations in liver function occur in the experimental obstructive jaundice model. Aims: We aimed to evaluate the effect of resveratrol on obstructive jaundice-induced changes in the small bowel ...
Volkan Temi, Erdem Okay, Abdullah Güneş, Turgay Şimşek, Mustafa Çekmen, Ümit Bilgili, Yeşim Gürbüz   +6 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

High urinary desmosine is associated with long-term mortality in patients with COPD

ERJ Open Research, 2023
Changhwan Kim, Yousang Ko, Jae Seung Lee, Chin Kook Rhee, Jin Hwa Lee, Ji-Yong Moon, Seong Yong Lim, Kwang Ha Yoo, Joon Beom Seo, Yeon-Mok Oh, Sang-Do Lee, Yong Bum Park   +11 more
doaj   +1 more source

Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial. [PDF]

, 2015
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and health-care costs. An incomplete response to the anti-inflammatory effects of inhaled corticosteroids is present in COPD.
Alyn Morice, Amanda J. Lee, Andrew Briggs, Andrew Wilson, Anita Sullivan, Anthony De Soyza, B Shah, BG Cosio, BG Cosio, BR Celli, CM Fletcher, David Price, E Stahl, G Cusack, GC Donaldson, GC Donaldson, Gladys McPherson, Graham Burns, Graham Devereux, H Chrystyn, H Chrystyn, H Chrystyn, H Chrystyn, Henry Chrystyn, JA Marwick, JC Bestall, JJ Soler-Cataluna, JK Quint, John Haughney, John Norrie, JR Hurst, JR Powell, JR Powell, JW Dodd, K Ito, K Ito, K Ito, K Ito, K Ohta, KC Farmer, Kirsty McCormack, KL Hattotuwa, L Hendeles, Lisa Davies, M Britton, M Ferrer, MC Cyr, MR Miller, P Dolan, P Sullivan, PA Ford, Peter Barnes, PJ Barnes, PJ Barnes, PW Jones, Rekha Chaudhuri, RG Barr, S Lim, Seonaidh Cotton, Shona Fielding, Simon Gompertz, SN Hunt, SV Culpitt, SV Culpitt, TA Seemungal, The EuroQol Group, WJ Jusko, WJ Jusko, Y To   +68 more
core   +4 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A comparison of curated gene sets versus transcriptomics-derived gene signatures for detecting pathway activation in immune cells

BMC Bioinformatics, 2020
Background Despite the significant contribution of transcriptomics to the fields of biological and biomedical research, interpreting long lists of significantly differentially expressed genes remains a challenging step in the analysis process.
Bin Liu, Patrick Lindner, Adan Chari Jirmo, Ulrich Maus, Thomas Illig, David S. DeLuca   +5 more
doaj   +1 more source

Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome [PDF]

, 2019
Background: Marfan syndrome (MFS) is an inherited connective tissue disorder characterized by ectopia lentis, aortic root dilation and dissection and specific skeletal features.
Bauters, Fré, De Backer, Julie, De Groote, Katya, De Wilde, Hans, De Wolf, Daniël, Dhondt, Karlien, Hertegonne, Katrien, Jordaens, Luc, Muiño Mosquera, Laura   +8 more
core   +1 more source

Obstruction Before the Obstruction [PDF]

Circulation: Heart Failure, 2020
Timothy A. Joseph, C. Charles Jain, William R. Miranda, Rick A. Nishimura   +3 more
openaire   +2 more sources