Results 101 to 110 of about 655,218 (318)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Nomogram for predicting early olfactory dysfunction in obstructive sleep apnea-hypopnea syndrome: a multicenter-based study

Frontiers in Neurology
ObjectiveTo develop and validate a clinical prediction model for olfactory dysfunction in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), evaluating the combined predictive value of polysomnography (PSG) parameters and clinical symptoms ...
Qingchun Pan, Qi Yang, Jing Huang, XueQin Mi, Bei Li   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Prognostic Factors Related to Sleep Quality in Patients With Obstructive Sleep Apnea After Positive Airway Pressure Therapy [PDF]

Journal of Rhinology
Background and Objectives This study aimed to evaluate the factors that influence deep sleep restoration in patients with obstructive sleep apnea (OSA) following positive airway pressure (PAP) therapy.
Dong Heun Park, Hangseok Choi, Kukjin Nam, Seung Hoon Lee, Min Young Seo   +4 more
doaj   +1 more source

OBSTRUCTION OF THE BOWELS. [PDF]

The Lancet, 1878
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openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The role of airway infection in chronic obstructive pulmonary disease

, 2006
PhDThis. thesis examines the role of respiratory bacterial and viral infection in the natural history of Chronic Obstructive Pulmonary Disease. The rationale for this study is basedu pon previous data demonstratingt hat airway bacterial colonisationi s
Wilkinson, Thomas Michael Alan
core  

Breathing and Breathlessness: Chronic Obstructive Pulmonary Disease in Uruguay [PDF]

, 2013
An increasingly common part of being human is living with chronic health problems for which management over time, and not cure, is the goal of medical treatment.
Wainwright, M., WAINWRIGHT, MEGAN,JULIE
core  

Proprioceptive changes impair balance control in individuals with chronic obstructive pulmonary disease

, 2013
Copyright @ 2013 Janssens et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source
Janssens, L, Chris Burtin, Decramer, M., Burtin, C., Alison K McConnell, Janssens Lotte, Marc Decramer, McConnell Alison K., Lotte Janssens, Burtin, Chris, Claeys Kurt, Kurt Claeys, Brumagne, S, Janssens, W, Simon Brumagne, Janssens, Wim, Pijnenburg, M, Claeys, K., Troosters, T., McConnell, AK, Decramer Marc, Brumagne, Simon, Janssens, L., Madelon Pijnenburg, Claeys, Kurt, Pijnenburg, Madelon, Decramer, M, Wim Janssens, Janssens Wim, Claeys, K, Thierry Troosters, Troosters, T, Brumagne, S., McConnell, Alison K., Brumagne Simon, Decramer, Marc, Burtin, C, Pijnenburg, M., Janssens, W., Troosters Thierry, Pijnenburg Madelon, Troosters, Thierry, Janssens, Lotte, Burtin Chris   +43 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source