Results 111 to 120 of about 306,427 (235)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Retrograde Percutaneous Closure of a Ventricular Septal Defect after Myectomy for Hypertrophic Obstructive Cardiomyopathy

, 2013
In patients with hypertrophic obstructive cardiomyopathy, hemodynamically significant ventricular septal defect after septal myectomy is a rare sequela that warrants closure. Percutaneous closure provides a safer alternative to repeated sternotomy, which
Singh, Vikas, O'Neill, William W., Clark, Pedro Martinez, Ghersin, Eduard, Bokhari, Syed S., Badheka, Apurva O.   +5 more
core   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Acute Angina in Anomalous Left Main Coronary Artery With Prepulmonic Course: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Although a prepulmonic left main coronary artery is usually considered a lower‐risk AAOCA subtype, it may still be associated with acute ischemic symptoms when significant atherosclerotic coronary artery disease is present. Multimodality imaging is essential for defining the coronary anatomy, and coronary artery bypass grafting may be the ...
Mohammad Rouzbahani, Sepehr Navabifar, Nafiseh Montazeri, Amirmasoud Rahimi, Alireza Hayati   +4 more
wiley   +1 more source

Biventricular Hypertrophic Cardiomyopathy in a Child with LEOPARD Syndrome: a Case Report

Journal of Interdisciplinary Medicine, 2017
Background: LEOPARD syndrome is a complex dysmorphogenetic disorder of inconstant penetrance and various morphologic expressions. The syndrome is an autosomal dominant disease that features multiple lentigines, electrocardiographic changes, eye ...
Blesneac Cristina, Șuteu Carmen-Corina, Bănescu Claudia, Benedek Theodora, Benedek Imre, Togănel Rodica   +5 more
doaj   +1 more source

Hypertrophic Cardiomyopathy With Superimposed Pre‐Eclampsia in a Grand Multiparous Woman

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT This case report highlights the importance of clinical vigilance, the role of echocardiography, and the benefits of guideline‐directed multidisciplinary management of pregnant women with HCM in resource‐limited settings. Advocating for comprehensive multidisciplinary care models is essential in optimizing maternal and fetal health outcomes ...
Prince Yaw Boahene, Benedict Kusi Ampofo, Solomon Gyabaah, Richard Naab Tembila, Kwabena Addow Opare‐Addo, Emmanuel Acheamfour Akowuah, Lambert Tetteh Appiah, Collins Kokuro   +7 more
wiley   +1 more source

Right Ventricular Dysfunction and Ventriculo‐Arterial Uncoupling in Heart Failure With Preserved Ejection Fraction: A Phenotype‐Specific Review of Mechanisms, Diagnosis, and Therapeutic Strategies

Clinical Cardiology, Volume 49, Issue 11, November 2026.
Right ventricular dysfunction affects 19%–33% of patients With heart failure With preserved ejection fraction and is associated With exercise intolerance, hospitalization, and mortality. Assessing right ventricular function and its coupling with the pulmonary circulation may improve risk stratification and support management tailored to distinct ...
Amarelle Chamoun, Talha Farooq, Suhayya Batool, Sadia Tameez‐ud—din, Muhammad Yousaf, Preet Memon, Mohsin Ali, Arun Kumar Maloth, F. N. U. Sawaira, Muhammad Taimur Khan, Mohammad Eisa Ali, Mansoor Khalid, Maleeha Pandit, Kamil Ahmad Kamil   +13 more
wiley   +1 more source

Prognostic Impact of Late Gadolinium Enhancement on Major Adverse Cardiovascular Events and Time‐Varying Attenuation of Risk in Dilated Cardiomyopathy

Clinical Cardiology, Volume 49, Issue 11, November 2026.
In 173 dilated cardiomyopathy patients, late gadolinium enhancement (LGE) independently predicted major adverse cardiovascular events, but its risk effect attenuated over ~34 months, while LVEDVi maintained stable long‐term prediction. Early CMR‐based risk stratification identifies a critical time window for intervention.
Liyuan Ma, Yuan Li, Huairong Zhang, Yan Zheng, Pei Wang, Yuanyuan Niu, Li Zhu   +6 more
wiley   +1 more source

Survival and sudden cardiac death after septal ablation for hypertrophic obstructive cardiomyopathy

, 2011
Reports of long-term survival and the risk of sudden cardiac death (SCD) after percutaneous transluminal septal myocardial ablation (PTSMA) in patients with hypertrophic obstructive cardiomyopathy (HOCM) are ...
Henning Kelbæk, Lars Køber, Jensen, Morten Kvistholm, Erik Jørgensen, Christian Hassager, Morten Kvistholm Jensen, Hassager, Christian, Havndrup, Ole, Helqvist, Steffen, Jørgensen, Erik, Ole Havndrup, Henning Bundgaard, Steffen Helqvist, Kelbæk, Henning, Køber, Lars, Bundgaard, Henning   +15 more
core   +1 more source

Tailored Amino Acid Treatment for Pediatric Patients With Mitochondrial Aminoacyl‐tRNA Synthetase Deficiencies

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Aminoacyl‐tRNA synthetases (ARSs) facilitate the loading of transfer RNAs with their cognate amino acids in the cytosol (ARS1), mitochondria (ARS2), or both (dual ARS). ARS deficiencies are clinically heterogeneous and can cause severe, occasionally fatal disease.
I. J. J. Muffels, G. Kok, Z. Tang, L. S. Medeiros, F. O. Poswar, W. P. Vermeij, R. Rodenburg, K. Smit, S. K. Sukumaran, S. B. Wortmann, L. Averdunk, J. Munch, J. Pak‐lam Ho, A. M. K. Kwok, E. E. S. Nieuwenhuis, P. M. van Hasselt, I. V. D. Schwartz, C. M. A. Lubout, A. M. Bosch, K. Koop, E. M. M. Hoytema van Konijnenburg, S. A. Fuchs   +21 more
wiley   +1 more source