Results 101 to 110 of about 306,427 (235)

The MYH7 c.2770G > A (p.Glu924Lys) mutation exhibits phenotypic heterogeneity in hypertrophic cardiomyopathy (HCM) and restrictive cardiomyopathy (RCM): a case report

BMC Cardiovascular Disorders
This study reports on a Chinese Han cardiomyopathy family line carrying the MYH7 c.2770G > A (p.Glu924Lys) mutation. This mutation has been shown to result in cross-generational phenotypic heterogeneity between hypertrophic cardiomyopathy (HCM) and ...
Yuanyuan Han, Haiyan Wang, Hongsheng Zhang, Manman Wang, Lijun Gan, Fanhua Meng   +5 more
doaj   +1 more source

Eighteen‐Month Real‐World Experience Using Mavacamten for Treatment of Obstructive Hypertrophic Cardiomyopathy in a Racially Diverse Population

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Patients with obstructive hypertrophic cardiomyopathy have increased symptomatic burden. Mavacamten was recently approved for treatment of obstructive hypertrophic cardiomyopathy based on 2 randomized controlled trials.
Diego Ramonfaur, Alessio Gasperetti, Victoria E. Blake, Bryana Rivers, Ali A. Kassamali, Edward K. Kasper, Lili A. Barouch, Katherine C. Wu, Jose A. Madrazo, Richard T. Carrick   +9 more
doaj   +1 more source

Hypertrophic cardiomyopathy in Donohue syndrome

, 2016
We report the case of a patient with Donohue syndrome who died of heart failure due to obstructive hypertrophic cardiomyopathy. A literature survey revealed that hypertrophic cardiomyopathy was present in 30% of these patients and was often fatal ...
Regenerative Medicine and Stem Cells, Cardiologie onderzoek 1, de Vroede, Monique A M J, Endocrinologie, MS Neonatologie, Cardiologie patientenzorg, Breur, Johannes M.P.J., Child Health, Termote, Jacqueline U.M.   +8 more
core  

Suspected etiologies of newly diagnosed non-ischemic cardiomyopathy in our study population.

, 2013
Values are n (%).HNCM – hypertrophic non-obstructive cardiomyopathy, HOCM – hypertrophic obstructive cardiomyopathy.
Reinhard Kandolf (207194), Karin A. L. Müller (320331), Ulrich Kramer (380008), Iris Müller (6263), Meinrad Gawaz (320341), Axel Bauer (380009), Christine S. Zuern (380010)   +6 more
core   +1 more source

Outcomes of Subcutaneous Implantable Cardioverter Defibrillators in Patients Being Considered for Heart Transplantation: A Retrospective Cohort Study

Pacing and Clinical Electrophysiology, EarlyView.
Overview of the study cohort and principal findings. ABSTRACT Introduction Subcutaneous implantable cardioverter defibrillators (S‐ICD) are an alternative to transvenous devices (TV‐ICD) in patients not requiring bradycardia pacing, resynchronization (CRT) or anti‐tachycardia pacing (ATP).
Rohan Joshua Krishnaswamy, Callum Alec Cherrett, Aaron Argyris Adonopulos, Peter Simon Macdonald, Christopher Simon Hayward, Kavitha Muthiah, Alasdair John Watson, Rajesh Natarajan Subbiah   +7 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Echocardiographic Changes Following Surgical Myectomy in Severely Symptomatic Obstructive Hypertrophic Cardiomyopathy: Insights From the SPIRIT‐HCM Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background In obstructive hypertrophic cardiomyopathy, myectomy improves symptoms, quality of life, and left ventricular (LV) outflow tract gradients. We prospectively evaluated the temporal changes in various echo parameters after myectomy.
Milind Y. Desai, Natalie Szpakowski, Albree Tower‐Rader, Barb Bittel, Agostina Fava, Susan Ospina, Bo Xu, Maran Thamilarasan, Amgad Mentias, Nicholas G. Smedira, Zoran B. Popovic   +10 more
doaj   +1 more source

Pharmacological and Non-Pharmacological Treatment of Obstructive Hypertrophic Cardiomyopathy

, 2017
INTRODUCTION: Hypertrophic obstructive cardiomyopathy has been rising in prevalence, due to increased awareness and advanced imaging. For the symptomatic patient, pharmacological management remains an effective approach to the majority of patients with ...
Srihari S. Naidu, Wilbert S. Aronow, Aronow, Wilbert S., Hidalgo, Luis F, Naidu, Srihari S., Luis F. Hidalgo   +5 more
core   +1 more source

Elevational variation in heart mass and suppression of hypoxia‐induced right ventricle hypertrophy in Andean leaf‐eared mice (Phyllotis)

The Journal of Physiology, EarlyView.
Abstract figure legend In lowland mammals that ascend to high elevation, hypoxia‐induced changes in the pulmonary circulation can give rise to hypoxic pulmonary hypertension (HPH) and associated right‐ventricle (RV) hypertrophy. Andean mice with broad elevational ranges have greater heart mass relative to body size at higher elevations, but they ...
Naim M. Bautista, Nathanael D. Herrera, Marcial Quiroga‐Carmona, Chandrasekhar Natarajan, Adriana Rico‐Cernohorska, Jorge Salazar Bravo, Graham R. Scott, Guillermo D'Elía, Zachary A. Cheviron, Jay F. Storz   +9 more
wiley   +1 more source