Results 61 to 70 of about 67,015 (304)

Evidence of evolution towards left midventricular obstruction in severe Anderson–Fabry cardiomyopathy

ESC Heart Failure, 2021
Aims In Fabry cardiomyopathy, left ventricular outflow tract obstruction mimicking hypertrophic cardiomyopathy is a very rare finding, with few cases reported and successfully treated with cardiac surgery. In our population of patients with Fabry disease
Francesca Graziani, Rosa Lillo, Elena Panaioli, Gionata Spagnoletti, Maurizio Pieroni, Paolo Ferrazzi, Antonia Camporeale, Elena Verrecchia, Ludovico Luca Sicignano, Raffaele Manna, Filippo Crea   +10 more
doaj   +1 more source

Cardiac Myosin Inhibitors as a Novel Treatment Option for Obstructive Hypertrophic Cardiomyopathy: Addressing the Core of the Matter

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2022
mid- ventricular, and post- SRT phenotypes. Patients with heart failure with preserved ejection fraction also represent a future target for CMIs given their mechanism of action.
Ahmad Masri, I. Olivotto
semanticscholar   +1 more source

Systematic Benchmarking of a Noise‐Tolerant Conductive Hydrogel Electrode for Epidermal Bioelectronics

Advanced Science, EarlyView.
General schematic of the approach. Abstract Conventional Silver/Silver Chloride (Ag/AgCl) electrodes remain the clinical standard for electrophysiological monitoring but are hindered by poor skin conformity, mechanical rigidity, and signal degradation, particularly under motion or sweat.
Nazmi Alsaafeen, Ioannis Ziogas, Shirina Alsaedi, Mouza Alshehhi, Shahd Almheiri, Adil Rehman, Khulood Al Shehhi, Hani Saleh, Ahsan Khandoker, Charalampos Pitsalidis, Antoun Khawaja, Anna‐Maria Pappa   +11 more
wiley   +1 more source

The influence of aortoseptal angulation on provocable left ventricular outflow tract obstruction in hypertrophic cardiomyopathy. [PDF]

, 2014
OBJECTIVES: Aortoseptal angulation (AoSA) can predict provocable left ventricular outflow tract obstruction (LVOTO) in patients with symptomatic hypertrophic cardiomyopathy (HCM).
Critoph, CH, Elliott, PM, Moon, JC, Pagourelias, ED, Pantazis, A, Salazar-Mendiguchía, J, Tome Esteban, MT   +6 more
core   +2 more sources

Serial Changes in Ventricular Strain in Symptomatic Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Insights From the VALOR-HCM Trial

Circulation Cardiovascular Imaging
BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy, VALOR-HCM (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction Therapy ...
Milind Y. Desai, Y. Okushi, A. Gaballa, Qiuqing Wang, J. Geske, A. Owens, S. Saberi, Andrew Wang, Paul C. Cremer, M. Sherrid, N. Lakdawala, A. Tower-Rader, D. Fermin, Srihari S. Naidu, K. Lampl, A. Sehnert, Steven E. Nissen, Zoran B Popović   +17 more
semanticscholar   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Identifying Obstructive Hypertrophic Cardiomyopathy from Nonobstructive Hypertrophic Cardiomyopathy: Development and Validation of a Model Based on Electrocardiogram Features

Global Heart, 2023
Background: The clinical presentation and prognosis of hypertrophic cardiomyopathy (HCM) are heterogeneous between nonobstructive HCM (HNCM) and obstructive HCM (HOCM). Electrocardiography (ECG) has been used as a screening tool for HCM.
Lanyan Guo, Zhiling Ma, Weiping Yang, Fuyang Zhang, Hong Shao, Liwen Liu, Chao Gao, Ling Tao   +7 more
doaj   +1 more source

Long‐Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER‐OLE Study

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease
Background The phase 2 PIONEER‐HCM (Phase 2 Open‐label Pilot Study Evaluating Mavacamten in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction) study showed that mavacamten improved left ventricular ...
A. Masri, Steven J. Lester, J. Stendahl, S. M. Hegde, A. Sehnert, G. Balaratnam, A. Shah, S. Fox, Andrew Wang   +8 more
semanticscholar   +1 more source

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

Cardiac biomarkers and effects of aficamten in obstructive hypertrophic cardiomyopathy: the SEQUOIA-HCM trial

European Heart Journal
Background and Aims The role of biomarker testing in the management of obstructive hypertrophic cardiomyopathy is not well defined. This pre-specified analysis of SEQUOIA-HCM (NCT05186818) sought to define the associations between clinical ...
C. Coats, A. Masri, R. Barriales-Villa, T. Abraham, D. Brinkley, B. Claggett, A. Hagège, S. M. Hegde, C. Ho, Ian J. Kulac, M. Lee, M. Maron, I. Olivotto, A. Owens, Scott D. Solomon, J. Tfelt-Hansen, Hugh Watkins, D. Jacoby, S. Heitner, S. Kupfer, F. Malik, L. Meng, A. Wohltman, J. Januzzi   +23 more
semanticscholar   +1 more source