Results 101 to 110 of about 290,807 (297)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Quantifying species’ geographic range changes: conceptual and statistical issues
Ecosphere, 2020 Geographic range is an important metric used to evaluate species’ environmental relationships. Additionally, a very small or rapidly shrinking range may indicate elevated extinction risk.
Craig Loehle
doaj +1 more source
Occupancy-driven optimization of building operations: Balancing energy, thermal comfort, and indoor air ...
Thara Al Mindeel (11006436)
core +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Indoor Air quality related to occupancy at an air-conditioned public building
Brazilian Archives of Biology and Technology, 2010 To characterize the influence of occupancy on the indoor air quality, a public office building with air-conditioning system was selected for this study.
Karina Ponsoni +1 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
California Fish and Wildlife JournalForty years of increasing fire size and severity in California’s Sierra Nevada were embodied by the 2021 Dixie Fire, which burned 389,837 ha between July and October, making it one of the largest, most destructive fires in California’s history ...
Luca Bielski, Connor Wood
doaj +1 more source
Australian Occupational Therapy JournalABSTRACTIntroduction‘Occupational experience’ (OE) is widely used within the occupational therapy profession. However, it lacks a clear and unified definition in the profession's consensus practice frameworks and seminal models. Therefore, this study aimed to examine how OE has been defined and described in both occupational therapy and occupational ...
Jennifer Budman +1 more
openaire +2 more sources