Results 41 to 50 of about 5,361,294 (297)

Functions of Coenzyme A and Acyl-CoA in Post-Translational Modification and Human Disease

Frontiers in Bioscience-Landmark
Coenzyme A (CoA) is synthesized from pantothenate, L-cysteine and adenosine triphosphate (ATP), and plays a vital role in diverse physiological processes. Protein acylation is a common post-translational modification (PTM) that modifies protein structure,
Jumin Xie, Zhang Yu, Ying Zhu, Mei Zheng, Yanfang Zhu   +4 more
doaj   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Multitarget antitumor effects of panacis japonici rhizoma

Frontiers in Pharmacology
Panax japonicus C.A. Mey., belonging to the genus Panax in the Araliaceae family, is a perennial drug plant. Its rhizomes, known traditional Chinese medicine (TCM) as Zhujieshen (Panacis Japonici Rhizoma), have a long history spanning thousands of years.
Xixing Fang, Xixing Fang, Xiao Yang, Xiao Yang, Changyuan Zhou, Di Zeng, Di Zeng, Zehua Hu, Zehua Hu, Xing Tu, Bao Yang, Bao Yang, Bao Yang, Yuanxin Hou, Yuanxin Hou   +14 more
doaj   +1 more source

Generic occurrence of rings in rotating systems

, 2000
In rotating scattering systems, the generic saddle-center scenario leads to stable islands in phase space. Non-interacting particles whose initial conditions are defined in such islands will be trapped and form rotating rings.
Benet, Benet, Ding, Ding, Dullin, Goldreich, Hénon, L Benet, Meyer, Smith, Smith, T.H Seligman, Tél   +12 more
core   +1 more source

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases

Frontiers in Bioscience-Landmark
Coenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes.
Jumin Xie, Xingyuan Chen, Mei Zheng, Jingzhe Zhu, Hui Mao   +4 more
doaj   +1 more source

Occurrence and distribution of citrus tatter leaf disease in Zhejiang and genetic diversity analysis of its pathogen [PDF]

Guoshu xuebao
[Objective] Citrus tatter leaf disease is a viral disease that harms citrus trees. Currently, it is showing an increasing trend of spreading and causing plant weakness, death, and even large-scale destruction of orchards.
LU Lianming, LIU Shunmin, AN Baoju, DU Danchao, HU Xiurong, PU Zhanxu, LÜ Jia   +6 more
doaj   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Retrospective analysis of mortality among children under 5 years of age in Huangshi over the period 2002–2022, China

BMC Public Health
Background The United Nations’ Millennium Development Goals and Sustainable Development Goals both underscore the critical need to reduce the under-five mortality rate globally.
Jumin Xie, Yihan Hong, Jianlin Yang, Yueming Yan, Shinuan Fei   +4 more
doaj   +1 more source

Balanophora polysaccharide improves renal injury and fibrosis in db/db diabetic nephropathy mice via NLRP3 inflammasome mediated inflammation

Frontiers in Pharmacology
IntroductionDiabetic nephropathy (DN) is a major complication of diabetes, with renal fibrosis leading to progressive renal function decline. Understanding interventions for renal injury and fibrosis in DN is vital, and given its complex pathogenesis ...
Chaoxi Tian, Chaoxi Tian, Aolong Ma, Tianying Song, Tianying Song, Fangyu Zhao, Fangyu Zhao, Jing Huang, Jing Huang, Jianhong Gao, Jianhong Gao, Honglin Yan, Xianbing Chen, Xianbing Chen   +13 more
doaj   +1 more source