Results 41 to 50 of about 1,977,117 (265)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Evolution of death trends and influencing factors of people living with HIV from 2003 to 2025 in Huangshi, China

BMC Public Health
Background This study aimed to analyze mortality trends, causes of death, and key prognostic factors among people living with HIV (PLWH) receiving antiretroviral therapy (ART) in Huangshi, Hubei Province, from 2003 to 2025, to inform the optimization of ...
Biao Fu, Zixuan Yang, Xuening Wang, Hongru Chen, Jumin Xie, Luman Li   +5 more
doaj   +1 more source

The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases

Frontiers in Bioscience-Landmark
Coenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes.
Jumin Xie, Xingyuan Chen, Mei Zheng, Jingzhe Zhu, Hui Mao   +4 more
doaj   +1 more source

Occurrence and distribution of citrus tatter leaf disease in Zhejiang and genetic diversity analysis of its pathogen [PDF]

Guoshu xuebao
[Objective] Citrus tatter leaf disease is a viral disease that harms citrus trees. Currently, it is showing an increasing trend of spreading and causing plant weakness, death, and even large-scale destruction of orchards.
LU Lianming, LIU Shunmin, AN Baoju, DU Danchao, HU Xiurong, PU Zhanxu, LÜ Jia   +6 more
doaj   +1 more source

Backdoors into Two Occurrences

Journal on Satisfiability, Boolean Modeling and Computation, 2020
Backdoor sets for the class CNF(2) of CNF-formulas in which every variable has at most two occurrences are studied in terms of parameterized complexity. The question whether there exists a CNF(2)-backdoor set of size k is hard for the class W [ 2 ], for both weak and strong backdoors, and in both cases it becomes fixed-parameter tractable when ...
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. This study aims to investigate the association between APM and
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
doaj   +1 more source

Microplastic exposure and human health risks across the life cycle: a focus on reproduction, development, and aging

Frontiers in Cell and Developmental Biology
Microplastic pollution has emerged as a critical global environmental and public health challenge. These small plastic particles of diverse origins are ubiquitously distributed in aquatic, atmospheric, terrestrial, and food systems, entering the human ...
Guosheng Liu, Guosheng Liu, Tian Shi, Tian Shi, Shengyao Tang, Shengyao Tang, Xia Huang, Xiao Liu, Xiao Liu   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Occurrence of ?whimper? singularities [PDF]

General Relativity and Gravitation, 1978
HOmogeneous space-times (i.e. those admitting a three-parameter group of isometries) are studied using the Newman Penrose formalism. It is found that solutions containing horizons depend on two fewer parameters than the most general solution, so that horizons and the associated whimper singularities are not stable features of homogeneous space-times ...
openaire   +2 more sources