Results 61 to 70 of about 1,983,500 (266)

Case Report: Uterine mesothelial cyst: a report of three cases and literature review

Frontiers in Medicine
ObjectiveMesothelioma cysts are benign tumor-like lesions derived from mesothelial cells. They mainly affect the peritoneum of the pelvic and abdominal cavities, and are more commonly found in the mesentery and greater omentum, while they are less likely
Jianfeng Huang, Wenxuan Yang, Yuqing Wang, Weiqing Huang, Daiyu Zhu   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Performance changes during and post-exercise in combined heat and hypoxia environments: a systematic review and network meta analysis

Journal of Translational Medicine
Background This study aims to compare exercise performance, as well as physiological, and psychological changes, when individuals exercise both during and after exposure to the heat environment (HEAT), the hypoxia environment (HYP), and the combined heat
Jianfeng Huang, Weiqing Huang, Wenxuan Yang, Jun Lei, Yuqing Wang, Xin Dong, Daiyu Zhu   +6 more
doaj   +1 more source

Dual-targeting CD73/PD-L1 bifunctional inhibitor: a promising cancer immunotherapy strategy

Frontiers in Immunology
ObjectivesThis work aims to design and characterize a novel bifunctional small molecule that simultaneously targets PD-L1 and CD73 to enhance the therapeutic efficacy of tumor immunotherapy.MethodsMultiple methodologies were integrated for compound ...
Jing-Jing Du, Sen Wu, Shiyun Cheng, Xiaobo Zeng, Binbin Cheng   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

INJURY RISK FACTORS IN CHILDREN AND YOUTH IN PHYSICAL / SPORTS ACTIVITY

Annales Kinesiologiae, 2015
Purpose: The aim of the article is to define the injury risk factors in physical/sports activity and how they may correlate.  Methods: A systematic review of electronic databases MEDLINE, Google Scholar, ScienceDirect and Cinahl in May 2015 has ...
Marina Dobnik
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source