Results 51 to 60 of about 10,829 (144)

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, EarlyView.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

GGOC‐AD: a mHealth tool to challenge obsessive‐compulsive related maladaptive beliefs in Spanish community adolescents: a randomized controlled trial

Child and Adolescent Mental Health, EarlyView.
Background Obsessive‐compulsive related maladaptive beliefs play an essential role in the development and maintenance of obsessive‐compulsive disorder (OCD). Nevertheless, there is a lack of accessible and widespread strategies capable of challenging such beliefs in the youth general population.
Yuliya Saman, Belén Pascual‐Vera, Ángel Carrasco, Marta Corberán, Odalis Merchán, Laura Carratalá‐Ricart, Sandra Arnáez, Guy Doron, María Roncero, Gemma García‐Soriano   +9 more
wiley   +1 more source

Do others comprehensive income, profit, and equity attributable impact external audit fee?

Journal of Accounting and Investment
Research aims: Fair value accounting, fairness, and transparency are the basis for other comprehensive income (OCI), profit, and equity attributable. This research aims to analyze the impact of adding this information on external audit fees, considering ...
Marhaendra Kusuma, Sri Luayyi
doaj   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Exploring Intuition in Auditing: A Mixed‐Methods Field Study

International Journal of Auditing, EarlyView.
ABSTRACT Several scholars have argued that intuition plays a significant role in auditor judgement and decision‐making (JDM); however, there is limited scientific insight into whether, to what extent and how intuition is perceived in practice. This mixed‐methods field study explores the perceived use of intuition in auditing.
Edwin Hummel, Joost van Buuren, Ap Dijksterhuis, Daniel H. J. Wigboldus, William M. van der Veld   +4 more
wiley   +1 more source

Bankruptcy Experience and Corporate Hedging

Journal of Business Finance &Accounting, EarlyView.
ABSTRACT We examine whether managers’ prior exposure to corporate bankruptcy shapes corporate risk‐management policies. Using detailed executive employment histories and hand‐collected derivative disclosures for a large sample of US public firms, we find that firms led by bankruptcy‐experienced (BE) CEOs are more likely to use cash‐flow hedges and ...
Taoran Guo, Abe de Jong, Lubna Rahman
wiley   +1 more source

Introduction: Fostering the Cultural Aspects of Doing Research

Forum: Qualitative Social Research, 2009
Framing the 14 contributions included in this special issue on "Advances in Qualitative Research in Ibero America" within the cultural complexity of our current world is the objective of this introduction.
César A. Cisneros Puebla, Robert B. Faux, Jo Moran-Ellis, Ercilia García-Álvarez, Jordi López-Sintas   +4 more
doaj  

Prevalence and Risk Factors of Occult HCV Infection in the Adult Population of Mexico City

Viruses
Occult HCV infection (OCI) is defined by the presence of HCV RNA in hepatocytes and/or peripheral blood mononuclear cells (PBMCs) without detectable HCV RNA or anti-HCV antibodies in plasma.
Luis Antonio Uribe-Noguez, María Erandhi Prieto-Torres, Luis Octavio Uribe-Noguez, José Antonio Mata-Marín, Carla Ileana Arroyo-Anduiza, Rebeca Paquentín-Jimenez, Alberto Chaparro-Sanchez, Wendy Guadalupe Vazquez-Gonzalez, Andrea Santos Coy-Arechavaleta, Ericka Nelly Pompa-Mera, Jesus Gaytán-Martínez, Julio Elias Alvarado-Yaah, Clara Esperanza Santacruz-Tinoco, Alicia Ocaña-Mondragón   +13 more
doaj   +1 more source

Towards Standardization of the Earth Observation Data Product Supply Chain – Are OCI Artifacts the Key to Ubiquitous and Scalable EO Data Handling? [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
The exponential growth of Earth Observation (EO) data generated by satellites demands scalable, efficient, and interoperable methods not only for storing and managing, but also for distributing data packages tailored to diverse use cases.
S. Achtsnit, S. Achtsnit, M. Rösel, S. Meißl   +3 more
doaj   +1 more source