Results 151 to 160 of about 203,616 (288)

Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response. [PDF]

Nat Commun
Zong L, Park B, Tekin-Turhan F, Kuribayashi W, Tanaka-Yano M, Li K, Beerman I.   +6 more
europepmc   +1 more source

Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid

Cell Proliferation, EarlyView.
By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao, Xiaowen Du, Qi Chen, Wenxin Mu, Shuning Lou, Xu Zhang, Min Xu, Jiting Li, Yuxuan Guo, Wanying Zhu, Yan Liu   +10 more
wiley   +1 more source

Psoriasis under B-cell depleting therapies in multiple sclerosis: a retrospective multicenter analysis. [PDF]

Ther Adv Neurol Disord
Kirschner P, Konen FF, Axhausen F, Ceylan U, Bucak E, Baumgart R, Masanneck L, Gingele S, Steinbrink K, Meuth SG, Gold R, Wolff S, Faissner S, Skripuletz T, Pfeuffer S, Pawlitzki M.   +15 more
europepmc   +1 more source

SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism

Cell Proliferation, EarlyView.
This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang, Juan He, Jing Zheng, Bing Shao, Lixin Shi, Miao Zhang   +5 more
wiley   +1 more source

Ultrafast Spectroscopy of Commercial Sunscreen Formulations in Thin Films and on a Skin Mimic. [PDF]

ACS Omega
Whittock AL, Woolley JM, Cébrian J, Stavros VG, Rodrigues NDN.   +4 more
europepmc   +1 more source

OCR-D

Archivalia, 2021
openaire   +2 more sources

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

Assessment of newly designed fonts for visual accessibility. [PDF]

PLoS One
Legge GE, Xiong Y, Gao Q, Gage R, Knickel T, Bigelow C.   +5 more
europepmc   +1 more source

“Queens of Ghost‐Land” 134 Years Later: Un‐Masking an Appalachian Witchcraft Accuser

The Journal of American Culture, EarlyView.
ABSTRACT In 1891, newspapers across America printed a story about witches in the Appalachian Mountains and the alleged powers they possessed to control their small farming community. The article was scathing in accusation and ultimately contributed to continued othering of the women profiled, increasing their visible vulnerabilities of class, gender ...
Aíne Norris
wiley   +1 more source

All the world's a stage: the drama of OCR psychology [PDF]

, 2004
Banyard, P
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