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Octopamine

Nature, 1977
Octopamine is highly concentrated in neurones of several invertebrate species. Unlike in mammals, octopaminergic neurones in invertebrates are spatially separated from catecholaminergic neurons. In identified nerve cells of Aplysia, however, this amine coexists with other putative neurotransmitters. Octopamine is synthesized in nerves from tyrosine and
J, Axelrod, J M, Saavedra
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Octopamine in invertebrates

Progress in Neurobiology, 1999
Octopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. It is present in relatively high concentrations in neuronal as well as in non-neuronal tissues of most invertebrate species studied. It functions as a model for the study of modulation in general.
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Brain contents of phenylethanolamine, m-octopamine and p-octopamine in the roman strains of rats

Brain Research, 1980
Abstract:The development of a radiochemical enzyme assay for p‐octopamine in 1969 led to its identification in a large number of invertebrate nerve systems and in mammalian sympathetic nerves. The original method by which p‐octopamine was measured has now been found to be nonspecific; however, modifications of this procedure can determine both m‐ and p‐
J C, David, J, Delacour
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Octopamine in the Lobster Nervous System

Nature New Biology, 1972
A search for catecholamines which might serve as transmitters in the lobster nervous system demonstrated only small amounts of dopamine (about 0.2 µg/g tissue) and failed to detect noradrenaline or adrenaline (limit of sensitivity, 0.1 µg g−1) (unpublished results of D. L.
D L, Barker, P B, Molinoff, E A, Kravitz
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Octopamine and locomotor activity of rats

Psychopharmacology, 1983
Intracerebroventricular administration of P-octopamine (OA) had opposite effects on locomotor activity depending on whether or not the rats were subjected to uncontrollable electric shocks. In unshocked rats, OA produced a large decrease in locomotor activity, but when the rats were subjected to unsignalled and uncontrollable electric shocks, a ...
J, Delacour, C, Guenaire
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Presence of Octopamine and an Octopamine Receptor in Crassostrea virginica.

In vivo
Octopamine is a biogenic amine first identified in octopus. It has been well studied in arthropods and a few gastropods, serving as a neurotransmitter and hormone. The presence of octopamine has rarely been reported in bivalves and has not been reported in Crassostrea virginica.
Kerri, Pryce   +8 more
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Excretion of octopamine metabolites in neuroblastoma

Clinica Chimica Acta, 1986
The urinary concentrations of o-hydroxymandelic acid, m-hydroxymandelic acid, p-hydroxymandelic acid, homovanillic acid and vanillylmandelic acid were determined in 57 healthy children and 9 patients with neuroblastoma. The concentrations of o-hydroxymandelic acid and p-hydroxymandelic were not significantly different for both groups whereas the ...
M W, Couch, D M, Greer, C M, Williams
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Responsiveness of neurogenic hearts to octopamine

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1975
Abstract 1. The neurogenic hearts of the horseshoe crab Limulus polyphemus, the spider Eurypelma marxi, and the lobster Homarus americanus were examined for their responsiveness to octopamine. 2. Octopamine always produced a moderate increase in the rate and strength of the heartbeat when applied to isolated heart preparations of the horseshoe crab ...
D S, Grega, R G, Sherman
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DISTRIBUTION AND TURNOVER OF OCTOPAMINE IN TISSUES

Journal of Neurochemistry, 1972
Abstract— Octopamine is a normally occurring amine in several species of animals. Particularly high concentrations are found in the crustacean central nerve cord. In the rat it is specifically localized to sympathetic nerve endings, has a subcellular distribution similar to that of norepinephrine, and is asymmetrically distributed in the CNS.
P B, Molinoff, J, Axelrod
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Octopamine fuels fighting flies

Nature Neuroscience, 2008
The neural basis of aggression is poorly understood. A study in this issue used genetic scalpels to dissect the circuitry of the fly brain and identified a small cluster of octopaminergic neurons that can make a fly fighting mad.
Christopher J, Potter, Liqun, Luo
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