Results 91 to 100 of about 804,614 (310)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Ophthalmologic manifestations of pseudoxanthoma elasticum

Oman Journal of Ophthalmology, 2018
Pseudoxanthoma elasticum is a hereditary disorder that affects primarily the elastic tissues in the skin, the eyes and the blood vessels.
Khrifi Zineb
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Nanoparticles laden in situ gel for sustained ocular drug delivery

Journal of Pharmacy and Bioallied Sciences, 2013
Proper availability of drug on to corneal surface is a challenging task. However, due to ocular physiological barriers, conventional eye drops display poor ocular bioavailability of drugs (< 1%).
Himanshu Gupta, Mohammed Aqil, Roop K Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal   +5 more
doaj   +1 more source

Coordinated optimization of visual cortical maps (II) Numerical studies [PDF]

, 2012
It is an attractive hypothesis that the spatial structure of visual cortical architecture can be explained by the coordinated optimization of multiple visual cortical maps representing orientation preference (OP), ocular dominance (OD), spatial frequency,
A Antonini, A Das, A Grabska-Barwinska, A Grinwald, A Jacobs, A Shmuel, A Soward, A Zepeda, AA Koulakov, AP Bartsch, B Chapman, BA Malomed, BJ Farley, BS Wang, C Blakemore, C Blakemore, C von der Malsburg, CE Giacomantonio, CF Stevens, CJ Shatz, CJ Shatz, CN Levelt, D Bensimon, D Boyer, D Boyer, D Mitchell, D Shulz, DC Johns, DE Mitchell, DE Mitchell, DE Mitchell, DL Adams, DL Adams, DL Ringach, DL Ringach, Dominik Heide, E Bartfeld, E Bodenschatz, E Erwin, E Erwin, EM Slimko, F Wolf, F Wolf, F Wolf, FH Busse, Fred Wolf, GG Blasdel, GG Blasdel, GG Blasdel, GJ Goodhill, H Nakagama, H Ritter, H Wassle, H Yu, HY Lee, HZ Shouval, JA Bednar, JA Bednar, JB Swift, JE Dennis, JR Villablanca, Justin C. Crowley, K Albus, K Lehmann, K Obermayer, K Obermayer, K Obermayer, K Ohki, KD Miller, KD Miller, KD Miller, KR Duffy, KR Jones, L Reichl, L Reichl, Lars Reichl, LE White, LE White, M Argentina, M Cynader, M Hammele, M Hübener, M Imbert, M Kaschube, M Kaschube, M Kaschube, M Kaschube, M Kaschube, M Sato, M Schnabel, M Weliky, MA Carreira-Perpinan, Matthias Kaschube, MC Crair, MC Cross, MW Cho, MW Cho, N Mayer, ND Mermin, NL Rochefort, NP Issa, NV Swindale, NV Swindale, NV Swindale, NV Swindale, NV Swindale, NV Swindale, NW Daw, Olaf Sporns, P Buisseret, P Buisseret, P Coullet, PC Bressloff, PN Brown, R Engelmann, RAW Galuske, RE Soodak, S Grossberg, S LeVay, S Löwel, S Löwel, S Löwel, S Rathjen, S Rathjen, S Schuett, SB Paik, SC Rao, Siegrid Löwel, SJ Espinosa, T Bonhoeffer, T Bonhoeffer, T Bonhoeffer, TN Wiesel, U Ernst, W Keil, W Keil, W Zhang, W Zimmermann, W Zimmermann, WH Bosking, X Xu, Y Diao, Y Fregnac, Y Fregnac, Y Fregnac, Y Kremer, Y Li, Y Li, Y Pomeau, Y Pomeau   +149 more
core   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Fatal Infection in Ferrets after Ocular Inoculation with Highly Pathogenic Avian Influenza A(H5N1) Virus

Emerging Infectious Diseases
Ocular inoculation of a clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) virus caused severe and fatal infection in ferrets. Virus was transmitted to ferrets in direct contact.
Jessica A. Belser, Xiangjie Sun, Joanna A. Pulit-Penaloza, Taronna R. Maines   +3 more
doaj   +1 more source

Adverse events associated with intraocular injection of anti-VEGF(bevacizumab) in retinal vein ccclusion: a case report [PDF]

, 2015
Introduction: Antiangiogenic agents are often administered for treatment of Branch Retinal Vein Occlusion (BRVO). Among them, Bevacizumab has noticeable antiangiogenic and antiedemigenic properties and possesses great capacity to penetrate the retinal ...
ARTICO, Marco, BOTTONE, Andrea, Domenica Piraino, Carmen, Mollicone, Antonella, PACELLA, Elena, PACELLA, FERNANDA, Romana Parisiella, Francesca, TURCHETTI, PAOLO   +7 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source