Results 101 to 110 of about 497,699 (317)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Congenital Aniridia and the Ocular Surface

, 2016
Aniridia is a congenital pan-ocular disorder caused by haplo-insufficiency of Pax6, a crucial gene for proper development of the eye. Aniridia affects a range of eye structures, including the cornea, iris, anterior chamber angle, lens, and fovea.
Fagerholm, Per,, Ihnatko, Robert,, Edén, Ulla, Lagali, Neil, Edén, Ulla,, Ihnatko, Robert, Fagerholm, Per, Lagali, Neil,   +7 more
core   +1 more source

Diagnostic accuracy of a prototype point-of-care test for ocular Chlamydia trachomatis under field conditions in The Gambia and Senegal. [PDF]

, 2011
BACKGROUND: The clinical signs of active trachoma are often present in the absence of ocular Chlamydia trachomatis infection in low prevalence and mass treated settings.
Sillah Ansumana, Edwards Tansy, Edward F Harding, Sillah, Ansumana, Sarr, I., Emma M. Harding-Esch, Martin J. Holland, Aura A. Andreasen, Molina, Sandra, Chrissy h Roberts, Harding-Esch Emma M., Sandra Molina, Isatou Sarr, Ansumana Sillah, Harding, Edward F, Bailey, R. L., Chrissy h. Roberts, Harding-Esch, E. M., Robin L Bailey, Andreasen, Aura A, Holland, Martin J, Molina, S., Andreasen Aura A., Roberts, Chrissy H, Sarr, Isatou, Holland Martin J., Molina Sandra, Schémann Jean-François, Sarr Boubacar, Sarr Isatou, Boubacar Sarr, Harding-Esch, Emma M, Schémann, Jean-François, David C. W. Mabey, Andreasen, A. A., Martin J Holland, Sillah, A., Roberts Chrissy h., Harding Edward F., Aura A Andreasen, Roberts, C. H., Mabey, D. C. W., Bailey Robin L., Holland, M. J., Edwards, Tansy, David C W Mabey, Emma M Harding-Esch, Tansy Edwards, Edward F. Harding, Sarr, Boubacar, Mabey David C. W., Edwards, T., Bailey, Robin L, Sarr, B., Harding, E. F., Mabey, David CW, Jean-François Schémann, Robin L. Bailey   +57 more
core   +1 more source

TFOS lifestyle: Impact of societal challenges on the ocular surface

, 2023
Societal factors associated with ocular surface diseases were mapped using a framework to characterize the relationship between the individual, their health and environment.
Liu, Y, Jones, L, Roshandel, D, Lekhanont, K, Kaevalin Lekhanont, Navas, A, Stefano Barabino, Kendrick Shih, Li, TJ, Yang Liu, Anna Tichenor, Riaz Qureshi, Danial Roshandel, Iyer, G, Geetha Iyer, Tianjing Li, Stapleton, F, Anthea Burnett, Alejandro Navas, Afsun Sahin, Shih, KD, Qureshi, R, Lyndon Jones, Obinwanne, CJ, Chukwuemeka Junior Obinwanne, Burnett, A, Fiona Stapleton, Barabino, S, Tichenor, A, Juan Carlos Abad, Abad, JC, Sahin, A   +31 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

TFOS Lifestyle: Impact of contact lenses on the ocular surface

, 2023
Several lifestyle choices made by contact lens wearers can have adverse consequences on ocular health. These include being non-adherent to contact lens care, sleeping in lenses, ill-advised purchasing options, not seeing an eyecare professional for ...
Ucakhan, Omur O., Tan, Jacqueline, Stanila, Adriana, Ulli Stahl, Rhee, Michelle K., Willcox, Mark DP, Efron, Nathan, Pult, Heiko, Jacobs, Deborah S, Heather Sheardown, Joseph P. Shovlin, Adriana Stanila, Downie, Laura E., Ucakhan, Omur O, Jacqueline Tan, Jacobs, Deborah S., Jalbert, Isabelle, Silvia Tavazzi, Stahl, Ulli, Willcox, Mark D. P., Tavazzi, Silvia, Bandamwar, Kalika, Isabelle Jalbert, Kalika Bandamwar, Rhee, Michelle K, Jones, Lyndon, Downie, Laura E, Lyndon Jones, Deborah S. Jacobs, Laura E. Downie, Sheardown, Heather, Heiko Pult, Nathan Efron, Mark D.P. Willcox, Michelle K. Rhee, Melissa Barnett, Shovlin, Joseph P., Barnett, Melissa, Shovlin, Joseph P, Omur O. Ucakhan   +39 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Ocular Manifestations of Emerging Flaviviruses and the Blood-Retinal Barrier

Viruses, 2018
Despite flaviviruses remaining the leading cause of systemic human infections worldwide, ocular manifestations of these mosquito-transmitted viruses are considered relatively uncommon in part due to under-reporting.
Sneha Singh, Ashok Kumar
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A Review on Ocular Biomechanic Models for Assessing Visual Fatigue in Virtual Reality

IEEE Access, 2018
With the wide spread of affordable virtual reality headsets, virtual environments are rapidly changing the way humans interact with reality. Understanding the effects of virtual environments on the mental and cognitive state is essential.
Julie Iskander, Mohammed Hossny, Saeid Nahavandi   +2 more
doaj   +1 more source