Results 91 to 100 of about 7,348 (254)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Harnessing Generative AI for Sustainable Supply Chains: Lean, Circular and Green Perspectives

Business Strategy and the Environment, EarlyView.
ABSTRACT Generative artificial intelligence is playing a significant role in the transformation of digital ecosystems by reinventing the processes of content generation, process automation, product innovation and customer experience. At the same time that these technologies are becoming more integrated into routine operations, the focus has shifted to ...
Ashutosh Singh, Rsha Alghafes, Judit Petra Koltai, Sushant Kumar Vishnoi   +3 more
wiley   +1 more source

Detecting communities when order and direction matter in social network analysis

Canadian Journal of Statistics, EarlyView.
Abstract A novel algorithm combining both node degree and edge betweenness (node degree+edge betweenness) is developed to highlight gradients in connectivity. It identifies communities within complex directed graphs. These are networks that are composed of actors who have ties that originate and end at themselves (self‐loops).
Benjamin Smith, Tyler Pittman, Wei Xu
wiley   +1 more source

Repurposing Registries: Completeness of Real‐World Data for Regulatory and HTA Purposes in Three Cancer‐Focused Registries

Clinical Pharmacology &Therapeutics, EarlyView.
Despite developments in supporting the identification and selection of fit‐for‐purpose registries, a translational gap remains between the original purposes of clinically focused registries and their current and future expected use in policymaking. This study aimed to assess the extent to which cancer‐focused registries collect essential data elements ...
Manon C. Wilpshaar, Doranne Hilarius, Luisa Prada, Ansgar Weltermann, Christine Leopold   +4 more
wiley   +1 more source

High‐Performance Wearable Triboelectric Nanogenerators Based on Polyethyleneimine‐Doped Cellulose Acetate for Self‐Powered Dynamic Signature Sensing and Verification

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A high‐performance wearable triboelectric nanogenerator (TENG) based on polyethyleneimine ‐doped cellulose acetate is demonstrated for dynamic signature authentication. The developed TENG with enhanced interfacial polarization and increased surface charge density exhibits excellent mechanical durability, environmental stability, and long‐term ...
Yoon‐Seo Choi, Han‐Bi Kang, Chae‐Eun Kim, Tae‐Jun Ha   +3 more
wiley   +1 more source

Eye morphometry, body size, and flexibility parameters in myopic adolescents

Scientific Reports
The aim of this study was to investigate the anatomical and physiological ocular parameters in adolescents with myopia and to examine the relations between refractive error (SER), ocular biometry, body size and flexibility parameters in myopic ...
Kristina Kuoliene, Egle Danieliene, Janina Tutkuviene   +2 more
doaj   +1 more source

Quantitative electroencephalographic measures during postmalarial epileptogenesis

Epilepsia, EarlyView.
Abstract Objective Severe malaria with neurologic involvement contributes significantly to the global burden of acquired pediatric epilepsy. We studied quantitative electroencephalographic (EEG) measures in postmalarial epileptogenesis. Methods A total of 186 patients, aged 6 months to 11 years, with confirmed central nervous system malaria were ...
Rasesh B. Joshi, Suzanna Mwanza, Hitten P. Zaveri, Joseph Kasolo, Angela Masempela, Thelma Musakanya, Tina Mwale, Violet Nambeye, Rosemary Nyriongo, Ruth A. Tembo, Christopher Cortina, Bo Zhang, Gretchen L. Birbeck, Alexander Rotenberg, Archana A. Patel   +14 more
wiley   +1 more source

Relationship between biometry, fovea, and choroidal thickness in Nigerian children with myopia

African Vision and Eye Health
Background: Understanding the relationship between biometric and structural changes in childhood myopia is necessary to effectively manage myopia progression.
Chukwuemeka Junior Obinwanne, Kovin S. Naidoo, Khathutshelo P. Mashige   +2 more
doaj   +1 more source

Corticocortical evoked potential amplitude is altered by cortical stimulation in epilepsy

Epilepsia, EarlyView.
Abstract Objective Neurostimulation is an established therapy for drug‐resistant epilepsy, but optimizing stimulation parameters remains a major challenge. Corticocortical evoked potential (CCEP) amplitude may serve as an immediate biomarker of neurostimulation effects, enabling rapid parameter optimization.
Bethany J. Stieve, Aaron F. Struck, Dillon Scott, Richard Chappell, Andrew T. Knox   +4 more
wiley   +1 more source

Research progress in photo‐controlled radical involved luminescence materials

FlexMat, EarlyView.
This review systematically dissects radical generation mechanisms, triplet‐exciton photophysics, material design strategies, and cutting‐edge applications in smart encryption, environmental sensing, and 3D printing. Abstract In recent years, photo‐controlled radical room‐temperature phosphorescent (RTP) materials have shown significant application ...
Sichen Meng, Shengwen Bao, Xiang Li, Shuaishuai Lu, Danfeng Ye, Ying Liu, Deli Sun, Hongwei Wu, Liangliang Zhu   +8 more
wiley   +1 more source