Results 101 to 110 of about 177,406 (274)

A WHRN mutation impacts ocular morphology in rhesus macaques

Frontiers in Cell and Developmental Biology
BackgroundRhesus macaques are increasingly used to model inherited sensory disorders, yet the phenotypic impact of naturally occurring variants in primate colonies often remains undefined.MethodsWe identified five rhesus macaques homozygous for a ...
Ana Ripolles-Garcia, Ana Raposo, Sophie M. Le, Jaeho Shim, Sangwan Park, Karolina Roszak, Kira H. Lin, Meher Khan, Sooyoung Lee, Rosie Thienpaitoon, Lillian Gao, Jun Wang, Marguerite F. Knipe, Timothy Stout, Jeffrey Rogers, Rui Chen, Ala Moshiri, Sara M. Thomasy, Sara M. Thomasy, Sara M. Thomasy   +19 more
doaj   +1 more source

Long‐Term Risk of Rheumatoid Arthritis in Individuals With Autism Spectrum Disorder: A Population‐Based Matched Cohort Study

Autism Research, EarlyView.
ABSTRACT To investigate the long‐term risk of rheumatoid arthritis (RA) among individuals with autism spectrum disorder (ASD), addressing potential immune comorbidity in ASD populations. A population‐based matched cohort was assembled using Swedish registers, including 46,164 individuals diagnosed with ASD between 1987 and 2017, matched to 4,634,895 ...
Evora Hailin Zhu, Stephen Z. Levine, Matilda Morin, Weiyao Yin, Benjamin Christofferson, Johan Askling, Natalia Rivera, Abraham Reichenberg, Joseph D. Buxbaum, Sven Sandin, Benjamin Hon Kei Yip   +10 more
wiley   +1 more source

Dry Eye Disease as a Cause of Refractive Errors After Cataract Surgery – A Systematic Review

Clinical Ophthalmology, 2023
Katarzyna Biela,1,2,* Mateusz Winiarczyk,1,* Dorota Borowicz,2,* Jerzy Mackiewicz1,* 1Department of Vitreoretinal Surgery, Medical University of Lublin, Lublin, 20079, Poland; 2Department of Ophthalmology, Provincial Hospital in Zamosc ...
Biela K, Winiarczyk M, Borowicz D, Mackiewicz J   +3 more
doaj  

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Clinical Characteristics of Ocular Mucous Membrane Pemphigoid: A Systematic Review and Meta-Analysis

Purpose: To synthesize the evidence and generate a combined weighted measure on the frequency of ocular manifestations of mucous membrane pemphigoid (OMMP).
Romero-Osorio M.J., Oliver-Hernández M.V., Romero-Santos S., Barragán A.M., Pardo-Pizza D., de-la-Torre A., Cifuentes-González C., Parra-Tanoux D., Bocanegra-Oyola N.   +8 more
core   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Adaptive imatinib regimens can mitigate cumulative toxicity while sustaining hemodynamic benefit: A model‐based simulation of the positioning imatinib for pulmonary arterial hypertension trial

British Journal of Clinical Pharmacology, EarlyView.
ABSTRACT Aims Imatinib improves hemodynamics in pulmonary arterial hypertension (PAH), but dose‐dependent toxicity has limited its clinical development. We aimed to quantify the dose–efficacy–toxicity relationship and evaluate alternative dosing strategies using data from the PIPAH trial.
Medhat M. Said, Robert B. de Mooij, Dian Jiao, Reitze J. Ovelgonne, Rami Biram, Juan Delgado‐SanMartin, Alexander M. K. Rothman, Sofia S. Villar, Andreas A. Roussakis, Jurjan Aman, Ron A. A. Mathôt, Eleonora L. Swart, Martin R. Wilkins, Imke H. Bartelink   +13 more
wiley   +1 more source

Anatomical Communication in Surgical Informed Consent Documents: An Exploratory Application of the Anatomical Clarity Framework

Clinical Anatomy, EarlyView.
ABSTRACT Surgical informed consent documents represent an important interface between anatomical knowledge and patient‐facing clinical information; however, no structured approach currently exists for evaluating how anatomy is represented and communicated within these materials.
Zeynep Nisa Karakoyun, Fulden Cantas Turkis, Deniz Tikici, Omer Faruk Karakoyun, Yalcin Golcuk   +4 more
wiley   +1 more source

Detecting communities when order and direction matter in social network analysis

Canadian Journal of Statistics, EarlyView.
Abstract A novel algorithm combining both node degree and edge betweenness (node degree+edge betweenness) is developed to highlight gradients in connectivity. It identifies communities within complex directed graphs. These are networks that are composed of actors who have ties that originate and end at themselves (self‐loops).
Benjamin Smith, Tyler Pittman, Wei Xu
wiley   +1 more source