Results 91 to 100 of about 5,246,989 (312)

Long-Term Clinical Outcomes of nDSAEK and Machine Learning-Based Prediction of Graft Survival in Corneal Endothelial Decompensation

Clinical Ophthalmology
Yuan Lin,1– 6,* Yiming Hu,7,* Zhiwen Xie,1– 6,* Xie Fang,1– 6 Shunrong Luo,1– 6 Xianwen Xiao,1– 6 Zhirong Lin,1– 6 Huping Wu1– 6 1Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, People’s ...
Lin Y, Hu Y, Xie Z, Fang X, Luo S, Xiao X, Lin Z, Wu H   +7 more
doaj  

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Bilateral corneal ulceration in ocular graft-versus-host disease

, 2013
William Stevenson, Hasanain Shikari, Ujwala S Saboo, Francisco Amparo, Reza Dana Cornea Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA Purpose: To report on corneal ulceration in ocular graft-versus-host disease (GVHD). Methods: This was a
Dana R, Shikari H, Saboo US, Stevenson W, Amparo F   +4 more
core  

Csf1–Csf1r expression and late circulating CSF1 elevation during P23H retinal degeneration

Experimental and Molecular Pathology
Retinitis pigmentosa (RP) is accompanied by retinal oxidative stress and neuroinflammation, but whether local retinal stress is associated with detectable circulating molecular changes remains unclear.
Yuzhuo Fan, Jiarui Li, Wei Du, Qiulin Deng, Xiaodong Chen, Kai Wang, Lvzhen Huang   +6 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Determination of Ocular Blood Flows with the Microsphere Method

, 2012
Adequate blood supply to the eye is an important prerequisite for normal visual function. Over the past 40 years our knowledge of ocular blood flow regulation has improved significantly.
Siv F. E. Nilsson, Albert Alm, Nilsson, Siv,, Alm, Albert,   +3 more
core   +1 more source

Integrative analysis of transcriptomics, single-cell RNA sequencing, and GraphBAN identifies de novo lipogenesis-associated genes and their potential roles in diabetic retinopathy

Frontiers in Immunology
BackgroundDiabetic retinopathy (DR) represents a key microvascular disorder resulting from prolonged diabetes mellitus. Hyperglycemia, a common driver of diabetes-related vision loss, can pathologically activate de novo lipogenesis (DNL); however, the ...
Zhenghong Jin, Zhenghong Jin, Zhenghong Jin, Yichen Dong, Yichen Dong, Yichen Dong, Rong Xue, Rong Xue, Rong Xue, Xialian Fan, Xialian Fan, Xialian Fan, Guangming Wan, Guangming Wan, Guangming Wan   +14 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Preservatives and ocular surface disease: a review

Ocular surface disease (OSD) is a complex condition that can cause a range of symptoms (eg, dryness, irritation, and pain) and can significantly impact the quality of life of affected individuals.
Messmer, Elisabeth M., Galor, Anat, Radcliffe, Nathan M., Baudouin, Christophe, Rapuano, Christopher J., Kahook, Malik Y.   +5 more
core   +1 more source

Incidence of symptomatic toxoplasma eye disease: aetiology and public health implications. [PDF]

, 1999
Ocular disease is the commonest disabling consequence of toxoplasma infection. Incidence and lifetime risk of ocular symptoms were determined by ascertaining affected patients in a population-based, active reporting study involving ophthalmologists ...
Murray, PI, D. T. DUNN, Parker, S P, Dunn, D T, S. P. PARKER, Dunn, DT, Masters, J, Pavesio, CE, Stanford, MR, P. I. MURRAY, Parker, SP, Lightman, S, Gilbert, RE, S. LIGHTMAN, R. E. GILBERT, P. D. GORMLEY, Gormley, PD, Gormley, P D, C. E. PAVESIO, M. R. STANFORD, J. MASTERS, Pavesio, C E, Gilbert, R E, Murray, P I; id_orcid, Stanford, M R   +24 more
core   +1 more source