Results 201 to 210 of about 30,941 (247)
Advanced Materials, EarlyView.Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan +6 more
wiley +1 more source
Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review
Advanced Materials, EarlyView.Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase +6 more
wiley +1 more source
True Closed‐Loop Recyclable Hydrogels Enabled by Imine Boronic Ester Crosslinking
Advanced Materials, EarlyView.Subtle molecular differences in imine boronic ester crosslinkers profoundly influence hydrogel properties. 2‐formylphenylboronic acid crosslinkers form previously undisclosed 3‐amino‐benzoxaborole heterocycles, enhancing elasticity despite lower crosslinking density compared to their 4‐formylphenylboronic acid counterparts.
Jenna A. King +5 more
wiley +1 more source
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Expert Opinion on Drug Delivery, 2006
Drug delivery to the eye is hampered by anatomical factors, including the corneal epithelium, the blood-aqueous barrier and the blood-retinal barrier. This review aims to outline the major routes of ocular drug delivery, including systemic, topical, periocular and intravitreal. The pharmacokinetics, the disadvantages and the clinical relevance of these
Deepta Ghate, Henry F Edelhauser
exaly +4 more sources
Drug delivery to the eye is hampered by anatomical factors, including the corneal epithelium, the blood-aqueous barrier and the blood-retinal barrier. This review aims to outline the major routes of ocular drug delivery, including systemic, topical, periocular and intravitreal. The pharmacokinetics, the disadvantages and the clinical relevance of these
Deepta Ghate, Henry F Edelhauser
exaly +4 more sources
Nanomaterials for Ocular Drug Delivery
Macromolecular Bioscience, 2012AbstractEfficient drug delivery to the eye remains a challenging task for pharmaceutical scientists. Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye, conventional drug delivery systems, such as eye drop solutions, suffer from low bioavailability.
Frank Gu, Lyndon Jones, Shengyan Liu
exaly +3 more sources
Advances in Ocular Drug Delivery
Current Eye Research, 2012Eye drops have long been the primary ocular drug delivery dosage form used to treat ocular disorders ranging from superficial conditions to intravitreal diseases. The ocular anatomical structure and physiological protective mechanisms are one of the most formidable barriers to drug penetration that have significantly reduced the drug's efficacy and ...
Rawas-Qalaji, Mutasem +1 more
openaire +3 more sources
2016
Although the eye is an accessible organ for direct drug application, ocular drug delivery remains a major challenge due to multiple barriers within the eye. Key barriers include static barriers imposed by the cornea, conjunctiva, and retinal pigment epithelium and dynamic barriers including tear turnover and blood and lymphatic clearance mechanisms ...
Burcin, Yavuz, Uday B, Kompella
openaire +2 more sources
Although the eye is an accessible organ for direct drug application, ocular drug delivery remains a major challenge due to multiple barriers within the eye. Key barriers include static barriers imposed by the cornea, conjunctiva, and retinal pigment epithelium and dynamic barriers including tear turnover and blood and lymphatic clearance mechanisms ...
Burcin, Yavuz, Uday B, Kompella
openaire +2 more sources
Review of Ocular Drug Delivery
Current Drug Delivery, 2006Successful treatment of eye diseases requires effective concentration of drug at the eye for sufficient period of time. Conventional ocular drug delivery including eye drops, systemic administration, ophthalmic ointments, is no longer sufficient to combat ocular diseases.
Yasmin, Sultana +3 more
openaire +2 more sources
Nanotechnology in ocular drug delivery
Drug Discovery Today, 2008Despite numerous scientific efforts, efficient ocular drug delivery remains a challenge for pharmaceutical scientists. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions and ointment. These conventional dosage forms suffer from the problems of poor ocular bioavailability, because of various anatomical and
Sanjeeb K, Sahoo +2 more
openaire +2 more sources
Ocular Drug Delivery: Nanomedicine Applications
Nanomedicine, 2007Nanocarriers, such as nanoparticles, liposomes and dendrimers, are used to enhance ocular drug delivery. Easily administered as eye drops, these systems provide a prolonged residence time at the ocular surface after instillation, thus avoiding the clearance mechanisms of the eye.
Vandervoort, Jo, Ludwig, Annick
openaire +3 more sources