Results 101 to 110 of about 102,886 (302)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Metabolic syndrome as a risk factor for high intraocular pressure: the Korea National Health and Nutrition Examination Survey 2008–2010

Diabetes, Metabolic Syndrome and Obesity, 2019
Yu Hyeon Yi,1,2 Young Hye Cho,3 Yun Jin Kim,1,2 Sang Yeoup Lee,3 Jeong Gyu Lee,1,2 Eun Hee Kong,4 Byung Mann Cho,5 Young Jin Tak,1,2 Hye Rim Hwang,1,2 Seung Hun Lee,1,2 Eun Ju Park3 1Department of Family Medicine, Pusan National University School of ...
Yi YH, Cho YH, Kim YJ, Lee SY, Lee JG, Kong EH, Cho BM, Tak YJ, Hwang HR, Lee SH, Park EJ   +10 more
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Supervised machine learning based multi-task artificial intelligence classification of retinopathies

, 2019
Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may particularly ...
Alam, Minhaj, Chan, R. V. P., Le, David, Lim, Jennifer I., Yao, Xincheng   +4 more
core   +1 more source

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

Advanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler, Tim Lange, Sophia‐Marie Bach, Soeren S. Lienkamp, Nicole Endlich   +4 more
wiley   +1 more source

Ophthalmic ocular hypertension an atypical case

Revista de Ciencias Médicas de Pinar del Río, 2018
Introduction: phacolytic ocular hypertension is a condition where an increase in intraocular pressure is observed; which is secondary to the obstruction of the trabecular meshwork due to the deposition of high molecular weight crystalline proteins and ...
Lialys Santos Díaz, Henry Pérez González, Gianina Moreano Amaut, Aimara Beades Martínez   +3 more
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Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

The effect of high intraocular pressure on enzymatic antioxidant system of uveal tissues in rabbits with experimental allergic uveitis

Journal of Ophthalmology, 2019
Background. Determining the influential mechanisms of high intraocular pressure on the development and course of non-infectious anterior uveitis is a relevant but understudied issue which requires a detailed study. Of particular interest, in this regard,
I.M. Mikheitseva, S.G. Kolmiichuk, T.I. Siroshtanenko, M.M. Trofimov, L.V. Zagrodska   +4 more
doaj   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

Advanced Science, EarlyView.
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab, Mehdi Salar Amoli, Tanmay Mukherjee, Maryam Bagheri, Boeun Hwang, Linqi Jin, Yamini Singh, Sophia Norton, Ashay Vishwas Bongirwar, Shweta Karnik, Lakshmi Prasad Dasi, Reza Avazmohammadi, Rene Romero, Holly D. Bauser‐Heaton, Vahid Serpooshan   +14 more
wiley   +1 more source

Hypoperfusive and hypertensive ocular manifestations in Takayasu arteritis

Clinical Ophthalmology, 2010
Jayanthi Peter1, Sarada David1, George Joseph2, Saban Horo1, Debashish Danda31Department of Ophthalmology, Schell Eye Hospital, Vellore, India; 2Department of Cardiology, Christian Medical College Hospital, Vellore, India; 3Department of Clinical ...
Jayanthi Peter, Sarada David, George Joseph et al   +2 more
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