Results 31 to 40 of about 6,718,311 (305)

Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders

, 2022
Substance P (SP) is a tachykinin expressed by various cells in the nervous and immune systems. SP is predominantly released by neurons and exerts its biological and immunological effects through the neurokinin receptors, primarily the neurokinin-1 ...
Ortiz, Gustavo, Dohlman, Thomas H., Musayeva, Aytan, Dana, Reza, Cho, Wonkyung, Chen, Yihe, Naderi, Amirreza, Ferrari, Giulio, Singh, Rohan Bir   +8 more
core   +1 more source

TFOS lifestyle:Impact of nutrition on the ocular surface [PDF]

, 2023
Nutrients, required by human bodies to perform life-sustaining functions, are obtained from the diet. They are broadly classified into macronutrients (carbohydrates, lipids, and proteins), micronutrients (vitamins and minerals) and water.
Malgorzata Mrugacz, Wolffsohn, James S., Flanagan, Judith, Ahmad, Sumayya, Maria Markoulli, Markoulli, Maria, Jose Benitez-del-Castillo, Edwards, Katie, Marc Labetoulle, Labetoulle, Marc, Downie, Laura E., James S. Wolffsohn, Jelle Vehof, Misra, Stuti, Willcox, Mark D.P., Barbara Caffery, Katie Edwards, Stuti L. Misra, Ziemanski, Jillian, Wolffsohn, James S, Jayashree Arcot, Willcox, Mark D. P., Sumeer Singh, Misra, Stuti L., Singh, Sumeer, Sheppard, John, Arita, Reiko, Downie, Laura E, Laura E. Downie, Mrugacz, Malgorzata, Judith Flanagan, Piera Versura, Arcot, Jayashree, John Sheppard, Sumayya Ahmad, Vehof, Jelle, Mark D.P. Willcox, Caffery, Barbara, Willcox, Mark D P, Benitez-Del-Castillo, Jose, Reiko Arita, Versura, Piera, Jillian Ziemanski   +42 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Cooperative role of MDSCs and Tregs in alum-induced alloimmune tolerance in corneal transplantation

Scientific Reports
Alum, a widely used adjuvant, has recently been recognized for its capacity to modulate immune responses beyond classical activation. In this study, we investigated whether alum-induced expansion of myeloid-derived suppressor cells (MDSCs) and their ...
Lifang Li, Yuping Han, Xiangrong Xie, Dakun Ren, Ying Zhang, Shaofeng Hao, Xuming Guo   +6 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Establishment of a nomogram model to predict malignant risk in patients with ocular surface squamous neoplasia and ocular surface squamous epithelial tumors

Frontiers in Oncology
ObjectiveTo develop and internally validate a nomogram to predict the probability that a clinically suspected ocular surface squamous epithelial tumor is histopathologically malignant.MethodsThis retrospective study included 92 patients with ocular ...
Xie Fang, Xie Fang, Xie Fang, Xie Fang, Xie Fang, Xie Fang, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Zhiwen Xie, Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Yuan Lin, Miaomiao Liu, Miaomiao Liu, Miaomiao Liu, Miaomiao Liu, Miaomiao Liu, Miaomiao Liu, Hanqiao Li, Hanqiao Li, Hanqiao Li, Hanqiao Li, Hanqiao Li, Hanqiao Li, Shunrong Luo, Shunrong Luo, Shunrong Luo, Shunrong Luo, Shunrong Luo, Shunrong Luo, Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Xianwen Xiao, Shangkun Ou, Shangkun Ou, Shangkun Ou, Shangkun Ou, Shangkun Ou, Shangkun Ou, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Huping Wu, Huping Wu   +53 more
doaj   +1 more source

Observation of the effect of posterior scleral reinforcement combined with orthokeratology and 0.01% atropine in the treatment of congenital myopia: a case report

BMC Ophthalmology, 2023
Background Myopia has recently emerged as a significant threat to global public health. The high and pathological myopia in children and adolescents could result in irreversible damage to eye tissues and severe impairment of visual function without ...
Chunxiao Yan, Fangkun Zhao, Shang Gao, Xiaoyu Liu, Taorui Yu, Yanan Mu, Lijun Zhang, Jun Xu   +7 more
doaj   +1 more source

Impact of blinking on ocular surface and tear film parameters

, 2018
PURPOSE:To investigate the influence of blinking on tear film parameters, ocular surface characteristics, and dry eye symptomology. METHODS:A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which
Jung Min Lee, Maria Markoulli, Tien, Leslie, Kim, Dabin, Markoulli, Maria, Craig, Jennifer, Alicia Han, Wang, Michael, Han, Alicia, Lee, Jung Min, Jennifer P. Craig, Michael T.M. Wang, Dabin Kim, Leslie Tien   +13 more
core   +1 more source

Modification of the technique for detection and follow-up of diseases of the anterior ocular segment using the conjunctival autofluorescence method [PDF]

, 2019
Every person is in constant interaction with the environmental factors, with the sun being the highest energy source. The electromagnetic spectrum includes rays of different wavelengths, with shortwave ultraviolet rays being an invisible, potential ...
Neshkinski, Evgeni; Medical University of Varna, Radeva, Mladena; Medical University of Varna, Grupcheva, Christina; Medical University of Varna, Andreev, Jordan; Medical University of Varna, Boyadzhieva, Mariya; Medical University of Varna   +4 more
core   +7 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source