Results 11 to 20 of about 541 (175)

Pathogenesis and treatment of multiple myeloma bone disease. [PDF]

Jpn Dent Sci Rev, 2021
Multiple myeloma (Plasma cell myeloma), a malignancy of the plasma cells, exhibits tumor expansion preferentially in the bone marrow and the development of bone-destructive lesions.
Hiasa M, Harada T, Tanaka E, Abe M.
europepmc   +3 more sources

The Protective Effects of Osteocyte-Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging. [PDF]

Adv Sci (Weinh), 2022
It is found that the osteocyte‐derived extracellular vesicles (OCY‐EVs) isolated from young osteocytes can ameliorate cognitive impairment and pathogenies of AD, but not OCY‐EVs isolated from aged osteocytes. OCY‐EV can transfer to the brain under physiological and pathological conditions. The study uncovers the role of OCY‐EVs as a regulator of brain,
Jiang YL, Wang ZX, Liu XX, Wan MD, Liu YW, Jiao B, Liao XX, Luo ZW, Wang YY, Hong CG, Tan YJ, Weng L, Zhou YF, Rao SS, Cao J, Liu ZZ, Wan TF, Zhu Y, Xie H, Shen L.   +19 more
europepmc   +2 more sources

Prey capture by the non-native carnivorous pitcher plant Sarracenia purpurea across sites in Britain and Ireland. [PDF]

Ecol Evol, 2022
We surveyed prey capture by the carnivorous pitcher plant Sarracenia purpurea at six sites in its non‐native range. We demonstrated that prey capture varies in ecologically significant ways between populations, but overall there is no difference in prey capture patterns in the plants non‐native compared to native range. Abstract The carnivorous pitcher
Whatmore R, Wood PJ, Dwyer C, Millett J.
europepmc   +2 more sources

Radiation Induces Bone Microenvironment Disruption by Activating the STING-TBK1 Pathway

Medicina, 2023
Background and Objectives: Damage to normal bone tissue following therapeutic irradiation (IR) represents a significant concern, as IR-induced bone microenvironment disruption can cause bone loss and create a more favorable environment for tumor ...
Yuyang Wang, Li Ren, Linshan Xu, Jianping Wang, Jianglong Zhai, Guoying Zhu   +5 more
doaj   +1 more source

The “Alluvial Mesovoid Shallow Substratum”, a new subterranean habitat [PDF]

, 2013
Received: April 5, 2013; Accepted: August 23, 2013; Published: October 4, 2013In this paper we describe a new type of subterranean habitat associated with dry watercourses in the Eastern Iberian Peninsula, the “Alluvial Mesovoid Shallow Substratum ...
Gilgado, José D., Herrero-Borgoñón, Juan J., Jiménez-Valverde, Alberto, Ortuño, Vicente M., Pérez-Suárez, Gonzalo, Sendra, Alberto   +5 more
core   +6 more sources

Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases. [PDF]

Orthop Surg
Due to the close connection between the autonomic nervous system and skeletal system, large amounts of evidence have shown that neuromodulation plays a crucial role in regulating bone metabolism. Clinically, neuromodulation has exhibited promising therapeutic effects in treating joint disorders by significantly reducing inflammation and clinical scores.
Xia R, Peng H, Zhu X, Suolang W, Pambayi STL, Yang X, Zeng Y, Shen B.   +7 more
europepmc   +2 more sources

Osteocyte RANKL Drives Bone Resorption in Mouse Ligature‐Induced Periodontitis

Journal of Bone and Mineral Research, Volume 38, Issue 10, Page 1521-1540, October 2023., 2023
ABSTRACT Mouse ligature‐induced periodontitis (LIP) has been used to study bone loss in periodontitis. However, the role of osteocytes in LIP remains unclear. Furthermore, there is no consensus on the choice of alveolar bone parameters and time points to evaluate LIP.
Mizuho Kittaka, Tetsuya Yoshimoto, Marcus E Levitan, Rina Urata, Roy B Choi, Yayoi Teno, Yixia Xie, Yukiko Kitase, Matthew Prideaux, Sarah L Dallas, Alexander G Robling, Yasuyoshi Ueki   +11 more
wiley   +1 more source

Single‐Cell Transcriptomics of Bone Marrow Stromal Cells in Diversity Outbred Mice: A Model for Population‐Level scRNA‐Seq Studies

Journal of Bone and Mineral Research, Volume 38, Issue 9, Page 1350-1363, September 2023., 2023
ABSTRACT Genome‐wide association studies (GWASs) have advanced our understanding of the genetics of osteoporosis; however, the challenge has been converting associations to causal genes. Studies have utilized transcriptomics data to link disease‐associated variants to genes, but few population transcriptomics data sets have been generated on bone at ...
Luke J Dillard, Will T Rosenow, Gina M Calabrese, Larry D Mesner, Basel M Al‐Barghouthi, Abdullah Abood, Emily A Farber, Suna Onengut‐Gumuscu, Steven M Tommasini, Mark A Horowitz, Clifford J Rosen, Lutian Yao, Ling Qin, Charles R Farber   +13 more
wiley   +1 more source

High Bone Mass Disorders: New Insights From Connecting the Clinic and the Bench

Journal of Bone and Mineral Research, Volume 38, Issue 2, Page 229-247, February 2023., 2023
ABSTRACT Monogenic high bone mass (HBM) disorders are characterized by an increased amount of bone in general, or at specific sites in the skeleton. Here, we describe 59 HBM disorders with 50 known disease‐causing genes from the literature, and we provide an overview of the signaling pathways and mechanisms involved in the pathogenesis of these ...
Dylan J.M. Bergen, Antonio Maurizi, Melissa M. Formosa, Georgina L.K. McDonald, Ahmed El‐Gazzar, Neelam Hassan, Maria‐Luisa Brandi, José A. Riancho, Fernando Rivadeneira, Evangelia Ntzani, Emma L. Duncan, Celia L. Gregson, Douglas P. Kiel, M. Carola Zillikens, Luca Sangiorgi, Wolfgang Högler, Ivan Duran, Outi Mäkitie, Wim Van Hul, Gretl Hendrickx   +19 more
wiley   +1 more source

Osteocytes Serve as a Progenitor Cell of Osteosarcoma [PDF]

, 2014
Osteosarcoma (OSA) is the most common primary bone tumor in humans. However, the cell of origin of OSA is not clearly defined although there is evidence that osteoblasts may serve as OSA progenitors.
Asai, Atkin, Baird, Barger, Barroga, Bellahcene, Berman, Bielack, Bielack, Bonewald, Cao, Czekanska, Fan, Fogh, Franz-Odendaal, Henderson, Jones, Kashima, Kato, Khanna, Kimura, Knowles, Kobayashi, Kunita, Lane, Lednicky, Lee, Levine, Marton, Mohseny, Mutsaers, Patane, Pautke, Pipas, Qin, Rhodes, Rodan, Schmidt, Sottnik, Sottnik, Su, Walkley, Wijenayaka, Woo, Wysolmerski, Ye, Yin, Yu, Zhang, Zhu   +49 more
core   +1 more source