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Mdm2 Promotes Odontoblast-like Differentiation by Ubiquitinating Dlx3 and p53

Journal of dentistry research, 2019
Dentin is an important structural component of the tooth. Odontoblast differentiation is an essential biological process that guarantees normal dentin formation, which is precisely regulated by various proteins.
H. Zheng   +4 more
semanticscholar   +1 more source

Odontoblast physiology

Experimental Cell Research, 2014
Odontoblasts are post-mitotic cells organized as a layer of palisade cells along the interface between the dental pulp and dentin. They are responsible for the formation of the physiological primary and secondary dentins. They synthesize the organic matrix of type I collagen and actively participate to its mineralization by secreting proteoglycans and ...
openaire   +2 more sources

PIEZO1 Promotes Odontoblast-Mediated Reactionary Dentinogenesis via SEMA3A

Journal of dentistry research
Located at the interface of the dentin–pulp complex, the odontoblasts are specialized cells responsible for dentin synthesis and nociceptive signal detection in response to external stimuli. Recent studies have shown that the mechanosensitive ion channel
P. Huang   +6 more
semanticscholar   +1 more source

Therapeutic Management of Demineralized Dentin Surfaces Using a Mineralizing Adhesive To Seal and Mineralize Dentin, Dentinal Tubules, and Odontoblast Processes.

ACS Biomaterials Science & Engineering, 2019
Dentin hypersensitivity is attributable to the exposed dentin and its patent tubules. We proposed the therapeutic management of demineralized dentin surfaces using a mineralizing adhesive to seal and remineralize dentin, dentinal tubules, and odontoblast
Ying Shi   +8 more
semanticscholar   +1 more source

Nucleoli of human odontoblasts

Archives of Oral Biology, 1972
Abstract Nucleoli of human odontoblasts were studied in smears stained with buffered toluidine blue at pH 5, for the demonstration of RNP-containing structures, including nucleoli. The odontoblasts were obtained from 5 premolars removed for orthodontic reasons.
openaire   +2 more sources

Berberine Accelerates Odontoblast Differentiation by Wnt/β-Catenin Activation

Cellular Reprogramming, 2019
Berberine, a Chinese medical herbal extract, plays a key role in antidiabetic, antiangiogenesis, anti-inflammatory, antimicrobial, anticancer, and antihypercholesterolemic.
A. Wu   +4 more
semanticscholar   +1 more source

Wedelolactone Enhances Odontoblast Differentiation by Promoting Wnt/β-Catenin Signaling Pathway and Suppressing NF-κB Signaling Pathway

Cellular Reprogramming, 2018
Wedelolactone is a multitarget natural plant compound with many pharmacological activities, including anti-inflammatory, anticancer, and antiosteoporosis. In this study, dental pulp stem cells (DPSCs) were treated with or without wedelolactone.
Chenfei Wang   +7 more
semanticscholar   +1 more source

Odontoblast: a mechano‐sensory cell

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2008
AbstractOdontoblasts are organized as a single layer of specialized cells responsible for dentine formation and presumably for playing a role in tooth pain transmission. Each cell has an extension running into a dentinal tubule and bathing in the dentinal fluid.
Henry, Magloire   +4 more
openaire   +2 more sources

Odontoblast commitment and differentiation

Biochemistry and Cell Biology, 1998
Histological and cytological organization confer specificity to the odontoblasts. These postmitotic, neural crest derived, polarized cells are aligned in a single layer at the periphery of the dental pulp and secrete the organic components of predentin-dentin.
openaire   +2 more sources

Epigenetic Signals during Odontoblast Differentiation

Advances in Dental Research, 2001
Odontoblast terminal differentiation occurs according to a tooth-specific pattern and implies both temporo-spatially regulated epigenetic signaling and the expression of specific competence. Differentiation of odontoblasts (withdrawal from the cell cycle, cytological polarization, and secretion of predentin/dentin) is controlled by the inner dental ...
LESOT H   +5 more
openaire   +3 more sources

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