Results 51 to 60 of about 461,827 (349)

The Olfactory Tubercle Encodes Odor Valence in Behaving Mice

Journal of Neuroscience, 2015
Sensory information acquires meaning to adaptively guide behaviors. Despite odors mediating a number of vital behaviors, the components of the olfactory system responsible for assigning meaning to odors remain unclear.
Marie A. Gadziola, Kate A Tylicki, Diana Christian, D. Wesson   +3 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Hand tool permits shrink sizing of assembled tubing [PDF]

, 1966
Portable tool sizes tubing ends without disassembling the tubing installation. The shrink sizing tool is clamped to the tubing and operated by a ratchet wrench.
Millett, A., Odor, M.
core   +1 more source

Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb [PDF]

, 2012
The reshaping and decorrelation of similar activity patterns by neuronal networks can enhance their discriminability, storage, and retrieval. How can such networks learn to decorrelate new complex patterns, as they arise in the olfactory system?
A Arevian, A Fantana, A Mouret, A Mouret, A Sahay, AM McNamara, B Johnson, B Winner, Boris S. Gutkin, C Linster, C Rochefort, CW Lin, D Chaudhury, D Rinberg, D Wilson, DA Wilson, DJ Heeger, E Yaksi, F David, F Kermen, F Lazarini, F Lazarini, GA Cecchi, GK Mak, GK Mak, GM Shepherd, Hermann Riecke, I Imayoshi, I Ortega-Perez, J Ninkovic, JT Davie, L Belnoue, L Petreanu, LM Kay, M Alonso, M Satou, M Valley, M Whitman, M Yamaguchi, MC Whitman, MD Döbrössy, MM Moreno, MT Wiechert, N Kaneko, N Mandairon, N Mandairon, N Mandairon, N Mandairon, N Mandairon, N Mandairon, N Miwa, O Escanilla, P Panzanelli, PA Brennan, PE Castillo, PM Lledo, Q Nai, R Pressler, RE Dolmetsch, RW Friedrich, RW Friedrich, S Sultan, S Sultan, S Sultan, S Wick, Siu-Fai Chow, SR Olsen, SS Magavi, Stuart D. Wick, SW Kuffler, SX Luo, T Shingo, TA Cleland, TA Cleland, TB Woolf, TK Yokoyama, V Breton-Provencher, V Egger, V Egger, W Kelsch, W Kim, Y Gao   +81 more
core   +6 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Chemical Characterization of Human Body Odor Headspace Components

Separations
This study focused on evaluating human body odor volatiles using a chamber approach. Ten participants were asked to sit inside the chamber for 1 h, while using SPME as the extraction technique for vapor sampling.
A. Celeste Medrano, Ariela Cantu, Edgar O. Aviles-Rosa, Nathaniel J. Hall, Michele N. Maughan, Jenna D. Gadberry, Paola A. Prada-Tiedemann   +6 more
doaj   +1 more source

Rational Design of Peptide-Functionalized Surface Plasmon Resonance Sensor for Specific Detection of TNT Explosive

Sensors, 2017
In this study, a rationally-designed 2,4,6-trinitrotoluene (TNT) binding peptide derived from an amino acid sequence of the complementarity-determining region (CDR) of an anti-TNT monoclonal antibody was used for TNT detection based on a maleimide ...
Jin Wang, Masaki Muto, Rui Yatabe, Takeshi Onodera, Masayoshi Tanaka, Mina Okochi, Kiyoshi Toko   +6 more
doaj   +1 more source

From NELA to EPOCH and beyond: enhancing the evidence base for emergency laparotomy. [PDF]

, 2016
Around 35,000 patients undergo emergency laparotomy surgery in the UK each year with an in-hospital 30-day mortality estimated as between 11 and 15 %.
Grocott, MP, Odor, PM
core   +1 more source

Sparse, Decorrelated Odor Coding in the Mushroom Body Enhances Learned Odor Discrimination

Nature Neuroscience, 2014
Sparse coding may be a general strategy of neural systems for augmenting memory capacity. In Drosophila melanogaster, sparse odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for
Andrew C. Lin, A. Bygrave, Alix de Calignon, Tzumin Lee, G. Miesenböck   +4 more
semanticscholar   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source