Results 161 to 170 of about 247,095 (344)

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

Homeric Studies, Feminism, and Queer Theory: Interpreting Helen and Penelope

, 2018
Nancy Sorkin Rabinowitz and Amy Richlin’s Feminist Theory and the Classics (1993) and Barbara F. McManus’ Classics and Feminism: Gendering the Classics (1997) provided ground-breaking surveys of the feminist revolution in classical studies, and their ...
Lesser, Rachel H.
core  

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Poststroke epilepsy is associated with vascular cognitive disorder in young stroke patients: The ODYSSEY study

Epilepsia, EarlyView.
Abstract Objective Cognitive disorder is common after stroke at a young age, especially in patients with poststroke epilepsy (PSE). Whether the causative mechanism is direct (due to epilepsy‐related network alterations) or indirect (due to effect‐modifiers such as stroke severity) is not fully understood.
Frederik J. Reitsma, Esmée Verburgt, Mijntje M. I. Schellekens, Nina A. Hilkens, Jamie I. Verhoeven, Mayte E. van Alebeek, Paul J. A. M. Brouwers, Renate M. Arntz, Gert W. van Dijk, Rob A. R. Gons, Inge W. M. van Uden, Tom den Heijer, Julia H. van Tuijl, Karlijn F. de Laat, Anouk van Norden, Sarah E. Vermeer, Marian S. G. van Zagten, Marieke J. H. Wermer, Paul J. Nederkoorn, Frank G. van Rooij, Ido R. van den Wijngaard, Paul L. M. de Kort, Roy P. C. Kessels, Anil M. Tuladhar, Robert J. van Oostenbrugge, Frank‐Erik de Leeuw, Rob P. W. Rouhl   +26 more
wiley   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Could old tide gauges help estimate past atmospheric variability? [PDF]

Climate of the Past
The surge residual is the non-tidal component of coastal sea level. It responds to the atmospheric circulation, including the direct effect of atmospheric pressure on the sea surface.
P. Platzer, P. Platzer, P. Ailliot, B. Chapron, B. Chapron, P. Tandeo, P. Tandeo, P. Tandeo   +7 more
doaj  

Diagnostic reassessment in patients previously diagnosed with childhood‐onset epilepsy during the transition to adult care: A retrospective cohort study in a tertiary epilepsy center

Epilepsia Open, EarlyView.
Abstract Objective To investigate the frequency, predictors, and clinical implications of diagnostic reassessment in patients previously diagnosed with childhood‐onset epilepsy during the transition period to adult care at a tertiary epilepsy center. Methods We conducted a retrospective cohort study of 317 patients previously diagnosed with childhood ...
Tetsuhiro Fukuyama, Masaru Nasuno, Manami Yabe, Makoto Nishioka, Yumi Hoshino, Takenori Natsume, Kohei Kanaya, Kyoko Takano, Tomoki Kaneko, Yushi Inoue   +9 more
wiley   +1 more source

Odyssey 2 : A mission toward Neptune and Triton to test General Relativity

, 2010
Odyssey 2 will be proposed in December 2010 for the next call of M3 missions for Cosmic Vision 2015-2025. This mission, under a Phase 0 study performed by CNES, will aim at Neptune and Triton. Two sets of objectives will be pursued.
Biancale, Richard, Christophe, Bruno, Courty, Jean-Michel, Dittus, Hansjörg, Foulon, Bernard, Lamine, Brahim, Lenoir, Benjamin, Lämmerzahl, Claus, Léon-Hirtz, Sylvie, Lévy, Agnès, Métris, Gilles, Reynaud, Serge, Selig, Hanns, Sohl, Frank, van Zoest, Tim, Wohl, Peter   +15 more
core   +1 more source